Synthesis of New Indazole Analogs of Curcumin as Antioxidant and Anti-inflammatory Candidates: An In Vitro Investigation

被引：0

作者：

Hariyanti, Hariyanti ^{[1
]}

Hayun, Hayun ^{[2
]}

Yanuar, Arry ^{[2
]}

Azminah, Azminah ^{[3
]}

机构：

[1] Univ Muhammadiyah Prof DR HAMKA, Fac Pharm & Sci, Dept Pharmaceut Biol, Jl Delima II/IV, Jakarta Timur 13460, Indonesia

[2] Univ Indonesia, Fac Pharm, Dept Pharmaceut Chem, Jl Lingkar Kampus Raya, Depok 16424, Indonesia

[3] Univ Surabaya, Fac Pharm, Dept Pharmaceut Chem, Jl Ngagel Jaya Selatan 169, Surabaya 60284, Indonesia

来源：

INDONESIAN JOURNAL OF CHEMISTRY | 2024年 / 24卷 / 05期

关键词：

analog indazole curcumin; anti-inflammatory; antioxidant; in vitro; BIOLOGICAL EVALUATION; DERIVATIVES; VIVO;

D O I：

10.22146/ijc.82443

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The development of analog curcumin compounds by modifying the structure of monocarbonyl into an analog indazole of curcumin (AIC) is recognized to have a great potential. Still, only a few reports have been available. Rarely occurring in nature, indazole molecules are typically created through chemical synthesis. Therefore, this study aimed to synthesize six new AIC compounds with a particular focus on testing in vitro antioxidant activity using the DPPH and FRAP methods, as well as anti-inflammatory activity using the protein denaturation method. The results showed that the compounds formed had high anti-inflammatory activity but low antioxidant activity. All synthesis products produced higher anti-inflammatory activity than standard diclofenac sodium and curcumin compounds. Specifically, compound 3a showed the highest antiinflammatory activity with an IC50 50 = 0.548 +/- 0.062 mu M. Therefore, it was concluded that compound 3a has the potential to be further studied for anti-inflammatory activity.

引用

页码：1556 / 1562

页数：7

共 27 条

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