Biological Roles and Clinical Therapeutic Applications of Tumor-Associated Macrophages in Colorectal Liver Metastasis

被引：0
作者：
Li, Shenghao [1 ,2 ]
Hao, Liyuan [1 ,2 ]
Hu, Xiaoyu [2 ]
机构：
[1] Chengdu Univ Tradit Chinese Med, Sch Clin Med, Chengdu, Sichuan, Peoples R China
[2] Hosp Chengdu Univ Tradit Chinese Med, Dept Infect Dis, Chengdu, Sichuan, Peoples R China
来源：
JOURNAL OF INFLAMMATION RESEARCH | 2024年 / 17卷
基金：
中国国家自然科学基金;
关键词：
colorectal liver metastasis; macrophage; TAMs; COLON-CANCER; M2; POLARIZATION; MOUSE MODEL; CELLS; PROGRESSION; RECEPTOR; MICROENVIRONMENT; GROWTH; TAMS; MIGRATION;
D O I：
10.2147/JIR.S493656
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Colorectal cancer (CRC) commonly metastasizes to the liver, and this poses a significant clinical challenge. Tumor- associated macrophages (TAMs), key players within the TME, play a significant role in promoting CRC metastasis by secreting various chemokines, growth factors, and cytokines. This review not only aims to enhance our knowledge of TAMs' functions in CRC progression and metastasis but also examines innovative therapeutic strategies to address the clinical problem of colorectal liver metastasis (CLM). By targeting TAMs, we may be able to develop more effective treatments and offer hope to patients suffering from this devastating disease.
引用
收藏
页码：8429 / 8443
页数：15
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