Fabrication of piezoelectric/conductive composite nerve conduits for peripheral nerve regeneration

被引：0

作者：

Bian, Taotao ^{[1
]}

Jiang, Yuhui ^{[1
]}

Cao, Jie ^{[1
]}

Wu, Wenpin ^{[1
]}

Zhang, Luzhong ^{[1
]}

Yang, Yumin ^{[1
]}

机构：

[1] Nantong Univ, Coinnovat Ctr Neuroregenerat, Minist Educ, Key Lab Neuroregenerat Jiangsu, Nantong 226001, Jiangsu, Peoples R China

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2025年 / 250卷

基金：

中国国家自然科学基金;

关键词：

Piezoelectric; Conductive; Nerve conduit; Peripheral nerve regeneration; GRAPHENE OXIDE; TISSUE REGENERATION; STIMULATION;

D O I：

10.1016/j.colsurfb.2025.114544

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Due to the complex regenerative microenvironment after peripheral nerve injury (PNI), developing a piezoelectric/conductive composite nerve guidance conduit (NGC) for repairing nerve defects remains a great challenge. The conductivity and piezoelectricity have been separately demonstrated to enhance the repair of PNI, yet there is a paucity of studies investigating the synergistic effects of both functions. Herein, a piezoelectric/ conductive nerve conduit composed of chitosan (CS), reduced graphene oxide (rGO), and poly-L-lactic acid (PLLA) was fabricated, which provided the conductivity, mechanical support and piezoelectricity. Tensile strength, conductivity, antibacterial activity, and cell viability of piezoelectric/conductive composite NGCs were evaluated. Piezoelectric/conductive composite NGCs exhibited electrical signal output capability and conductive performance. Moreover, rGO significantly promoted cell proliferation and adhesion. Overall, the piezoelectric/ conductive CS/rGO/PLLA nerve conduit shows great promise as a potential treatment of PNI.

引用

页数：10

共 64 条

[1] Synergistic effects of conductive PVA/PEDOT electrospun scaffolds and electrical stimulation for more effective neural tissue engineering [J].