Liquid-liquid phase separation: a new perspective on respiratory diseases

被引：4

作者：

Wang, Li ^{[1
,2
]}

Wang, Yongjun ^{[1
]}

Ke, Zhangmin ^{[1
]}

Wang, Zexu ^{[1
]}

Guo, Yufang ^{[1
]}

Zhang, Yunlei ^{[1
]}

Zhang, Xiuwei ^{[1
]}

Guo, Zhongliang ^{[2
]}

Wan, Bing ^{[1
]}

机构：

[1] Nanjing Med Univ, Affiliated Jiangning Hosp, Dept Resp & Crit Care Med, Nanjing, Peoples R China

[2] Nanjing Med Univ, Shanghai East Clin Med Coll, Nanjing, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷

基金：

中国国家自然科学基金;

关键词：

liquid-liquid phase separation; membrane-less organelle; biomolecular condensates; respiratory diseases; lung; STRESS GRANULES; PROTEIN; RNA; MECHANISMS; TRANSITION; RESISTANCE; ACTIVATE; ELEMENTS; BIOLOGY;

D O I：

10.3389/fimmu.2024.1444253

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Liquid-liquid phase separation (LLPS) is integral to various biological processes, facilitating signal transduction by creating a condensed, membrane-less environment that plays crucial roles in diverse physiological and pathological processes. Recent evidence has underscored the significance of LLPS in human health and disease. However, its implications in respiratory diseases remain poorly understood. This review explores current insights into the mechanisms and biological roles of LLPS, focusing particularly on its relevance to respiratory diseases, aiming to deepen our understanding and propose a new paradigm for studying phase separation in this context.

引用

页数：13

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