A Multicomponent [2+2+1] Cascade Cyclization to Synthesize Thiazol-2(3H)-one

被引：0
|
作者：
Wang, Mingxu [1 ]
Gong, Yuchen [1 ]
Shi, Yaolian [1 ]
Zhao, Qihai [1 ]
Zhao, Xiao-Jing [1 ]
Li, Ganpeng [1 ]
He, Yonghui [1 ]
机构：
[1] Yunnan Minzu Univ, Sch Ethn Med, Key Lab Chem Ethn Med Resources, Key Lab Nat Prod Synthet Biol Ethn Med Endophytes, Kunming 650500, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 23期
关键词：
ELECTROCHEMICAL SYNTHESIS; STRATEGIES; CHEMISTRY;
D O I：
10.1021/acs.joc.4c01800
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A multicomponent [2+2+1] tandem cyclization of alkynones with amines and water using potassium thiocyanate as electrolyte and raw material to access thiazol-2(3H)-ones has been developed. This transformation proceeded smoothly via electrocatalytic oxidative C-H bond thiolation, and nucleophilic cascade cyclization to build the (C-S/C-N) bonds to construct the C-O bond. The reaction avoided using transition metal catalysts or oxidation reagents, making it more sustainable and renewable.
引用
收藏
页码：17778 / 17788
页数：11
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