A Multicomponent [2+2+1] Cascade Cyclization to Synthesize Thiazol-2(3H)-one

被引：0

作者：

Wang, Mingxu ^{[1
]}

Gong, Yuchen ^{[1
]}

Shi, Yaolian ^{[1
]}

Zhao, Qihai ^{[1
]}

Zhao, Xiao-Jing ^{[1
]}

Li, Ganpeng ^{[1
]}

He, Yonghui ^{[1
]}

机构：

[1] Yunnan Minzu Univ, Sch Ethn Med, Key Lab Chem Ethn Med Resources, Key Lab Nat Prod Synthet Biol Ethn Med Endophytes, Kunming 650500, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 23期

关键词：

ELECTROCHEMICAL SYNTHESIS; STRATEGIES; CHEMISTRY;

D O I：

10.1021/acs.joc.4c01800

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A multicomponent [2+2+1] tandem cyclization of alkynones with amines and water using potassium thiocyanate as electrolyte and raw material to access thiazol-2(3H)-ones has been developed. This transformation proceeded smoothly via electrocatalytic oxidative C-H bond thiolation, and nucleophilic cascade cyclization to build the (C-S/C-N) bonds to construct the C-O bond. The reaction avoided using transition metal catalysts or oxidation reagents, making it more sustainable and renewable.

引用

页码：17778 / 17788

页数：11

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