MgMOF-loaded multifunctional scaffold with anti-infection and osteogenesis for bone regeneration

被引：0

作者：

Su, Qin ^{[1
]}

Chen, Shunyu ^{[1
]}

Xiao, Xiufeng ^{[1
]}

机构：

[1] Fujian Normal Univ, Coll Chem & Mat Sci, Engn Res Ctr Ind Biocatalysis, Fujian Prov Key Lab Adv Mat Oriented Chem Engn,Fuj, Fuzhou 350007, Fujian, Peoples R China

来源：

MATERIALS LETTERS | 2025年 / 382卷

关键词：

3D printed scaffold; Methacrylated gelatin; Quaternary chitosan; Magnesium-organic framework; Anti-infection ability; Osteogenic capability;

D O I：

10.1016/j.matlet.2024.137861

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

In this study, quaternary chitosan(QCS) together with a magnesium-organic framework (MgMOF) constructed by coordinating Mg2+ with gallic acid(GA) were incorporated into methacrylated gelatin(GelMA) substrate to develop a multifunctional MgMOF@GelMA/QCS composite scaffold based on cryogenic 3D printing technique. The results indicated that the incorporated QCS and the released Mg2+ and GA with the degradation of MgMOF endowed the 3D printed GelMA scaffold with excellent antibacterial and anti-inflammatory activity. Furthermore, in vitro cell culture assays revealed that the prepared MgMOF@GelMA/QCS scaffold exhibited a good cytocompatibility and osteogenic activity to facilitate the growth and osteogenic differentiation of MC3T3-E1 osteoblasts, demonstrating a great potential for bone tissue engineering applications.

引用

页数：5