Human papillomavirus genotype distribution among high-grade cervical lesions in French women born between 1972 and 1993

被引：0

作者：

Lenoir, Philomene ^{[1
]}

Guillet, Julie ^{[2
]}

Desmarets, Maxime ^{[3
]}

Baraquin, Alice ^{[4
]}

Ramanah, Rajeev ^{[1
]}

Rousse, Justine ^{[3
]}

Mougin, Christiane ^{[4
,5
]}

Lepiller, Quentin ^{[4
,6
,7
]}

Pretet, Jean-Luc ^{[5
,6
,8
]}

机构：

[1] CHU Besancon, Serv Gynecol, F-25000 Besancon, France

[2] Univ Lorraine, Fac Odontol Lorraine, Dept Chirurg Orale, Nancy, France

[3] CHU Besancon, Unite methodol Rech Clin epidemiol & sante publ, F-25000 Besancon, France

[4] CHU Besancon, Ctr Natl Reference Papillomavirus, F-25000 Besancon, France

[5] Univ Marie & Louis Pasteur, UMR RIGHT U1098, F-25000 Besancon, France

[6] Univ Marie & Louis Pasteur, CHU Besancon, CNRS, Chronoenvironm UMR 6249, F-25000 Besancon, France

[7] CHU Besancon, Lab virol, F-25000 Besancon, France

[8] CHU Besancon, Lab Biol Cellulaire, F-25000 Besancon, France

来源：

JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION | 2025年 / 54卷 / 05期

关键词：

HPV; Cervical cancers; Vaccine-preventable genotypes; INTRAEPITHELIAL NEOPLASIA; VACCINE; PERCEPTIONS; INFECTION;

D O I：

10.1016/j.jogoh.2025.102945

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Background: Implementation of HPV vaccination programmes may induce significant changes in the distribution of HPV genotypes detected in cervical (pre-)cancers. Methods: In a multicentre study in France, we investigated the distribution of HPV genotypes using a sensitive molecular technique in 611 histological specimens diagnosed with high-grade lesions (CIN2/3) in a large cohort of women born between 1972 and 1993. Women born after 1983 were potentially vaccinated because of their young age. Results: High-risk HPV genotypes were detected in 93.4 % of women and 24.4 % had a multiple infections. HPV16/18 genotypes were more frequently associated with CIN3 than with CIN2 lesions (66 % vs. 57 %, p = 0.045). The prevalence of HPV16 and HV18 genotypes did not change according to the year of birth. Conclusion: Contrary to previous descriptions in countries with a high HPV vaccination coverage, we did not observe difference in the prevalence of HPV16 and HPV18 genotypes in CIN2/3 lesions after the introduction of HPV vaccination in France, in a context of low national vaccination coverage. ClinicalTrials.gov ID: NCT04167501

引用

页数：5

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