The Current Landscape of 1,2,3-triazole Hybrids With Anticancer Therapeutic Potential: Part II

Chemotherapy has been identified as a validated and critically important strategy for the treatment of cancer, but multidrug resistance and serious side effects remain grand challenges for effective cancer therapy. This highlights the urgent need for the development of alternative chemical entities that can modulate more than one biological target with high specificity and multitargeted mechanism of action in the disease progression pathway. 1,2,3-Triazole hybrids have the potential to act on dual/multiple targets in cancer cells simultaneously and possess potent broad-spectrum activity against various cancers, including drug-resistant forms. Thus, 1,2,3-triazole hybrids are valuable scaffolds in the treatment and eradication of cancer. This review provides a comprehensive overview of the evolving landscape of 1,2,3-triazole hybrids with their in vitro and in vivo anticancer potential, and the structure-activity relationships as well as mechanisms of action are also discussed, covering articles published from 2021 onward.