Organelle-oriented nanomedicines in tumor therapy: Targeting, escaping, or collaborating?

被引：1

作者：

Tan, Kexin ^{[1
,2
]}

Zhang, Haiyang ^{[1
,2
]}

Yang, Jianyuan ^{[1
,2
]}

Wang, Hang ^{[3
]}

Li, Yongqiang ^{[3
]}

Ding, Guqiao ^{[3
]}

Gu, Ping ^{[1
,2
]}

Yang, Siwei ^{[3
]}

Li, Jipeng ^{[1
,2
]}

Fan, Xianqun ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Shanghai Key Lab Orbital Dis & Ocular Oncol, Dept Ophthalmol,Sch Med, Shanghai 200011, Peoples R China

[2] Minist Educ, Ctr Basic Med Res & Innovat Visual Syst Dis, Shanghai 200011, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Microsyst & Informat Technol, Natl Key Lab Mat Integrated Circuits, Joint Lab Graphene Mat & Applicat, Shanghai 200050, Peoples R China

来源：

BIOACTIVE MATERIALS | 2025年 / 49卷

关键词：

Organelle targeting; Nanomedicine; Precise tumor therapy; Escape; Collaboration; ENDOPLASMIC-RETICULUM STRESS; MITOCHONDRIA-ASSOCIATED MEMBRANES; NUCLEAR-PORE COMPLEX; ARTIFICIAL-INTELLIGENCE; MOLECULAR-MECHANISMS; CONTACT SITES; CANCER-CELLS; NANOPARTICLES; DELIVERY; BREAST;

D O I：

10.1016/j.bioactmat.2025.02.040

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Precise tumor therapy is essential for improving treatment specificity, enhancing efficacy, and minimizing side effects. Targeting organelles is a key strategy for achieving this goal and is a frontier research area attracting a considerable amount of attention. The concept of organelle targeting has a significant effect on the structural design of the nanodrugs employed. Most notably, the intricate interactions among different organelles in a tumor cell essentially create a unified system. Unfortunately, this aspect might have been somewhat overlooked when existing organelle-targeting nanodrugs were designed. In this review, we underscore the synergistic relationship among the various organelles and advocate for a holistic view of organelle-targeting design. Through the integration of biology and material science, recent advancements in organelle targeting, escaping, and collaborating are consolidated to offer fresh perspectives for the development of antitumor nanomedicines.

引用

页码：291 / 339

页数：49

共 421 条

[11] The interactions of subcellular organelles in pulmonary fibrosis induced by carbon black nanoparticles: a comprehensive review [J].