Nutrition: A non-negligible factor in the pathogenesis and treatment of Alzheimer's disease

被引：1
作者：
Wen, Boye [1 ,2 ]
Han, Xiaodong [1 ,2 ]
Gong, Jin [3 ]
Wang, Pin [1 ,2 ]
Sun, Wenxian [1 ,2 ]
Xu, Chang [1 ,2 ]
Shan, Aidi [1 ,2 ]
Wang, Xin [1 ,2 ]
Luan, Heya [1 ,2 ]
Li, Shaoqi [3 ]
Li, Ruina [4 ]
Guo, Jinxuan [3 ]
Chen, Runqi [4 ]
Li, Chuqiao [1 ,2 ]
Sun, Yao [1 ,2 ]
Lv, Sirong [1 ,2 ]
Wei, Cuibai [1 ,2 ]
机构：
[1] Capital Med Univ, Xuanwu Hosp, Innovat Ctr Neurol Disorders, Natl Clin Res Ctr Geriatr Dis, 45 Changchun St, Beijing 100053, Peoples R China
[2] Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Dis, Dept Neurol, 45 Changchun St, Beijing 100053, Peoples R China
[3] Changchun Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Jingyue Natl High tech Ind Dev Zone, Changchun, Peoples R China
[4] Beihang Univ, Sch Biol Sci & Med Engn, Beijing, Peoples R China
来源：
ALZHEIMERS & DEMENTIA | 2025年 / 21卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Alzheimer's disease; cognition; diet pattern; nutrition; BODY-MASS INDEX; MILD COGNITIVE IMPAIRMENT; COMMUNITY-DWELLING PATIENTS; TRANSGENIC MOUSE MODEL; WEIGHT-LOSS; DOCOSAHEXAENOIC ACID; VITAMIN-D; INSULIN-RESISTANCE; OLDER-ADULTS; CHOLINESTERASE-INHIBITORS;
D O I：
10.1002/alz.14547
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Alzheimer's disease (AD) is a degenerative disease characterized by progressive cognitive dysfunction. The strong link between nutrition and the occurrence and progression of AD pathology has been well documented. Poor nutritional status accelerates AD progress by potentially aggravating amyloid beta (A beta) and tau deposition, exacerbating oxidative stress response, modulating the microbiota-gut-brain axis, and disrupting blood-brain barrier function. The advanced stage of AD tends to lead to malnutrition due to cognitive impairments, sensory dysfunctions, brain atrophy, and behavioral and psychological symptoms of dementia (BPSD). This, in turn, produces a vicious cycle between malnutrition and AD. This review discusses how nutritional factors and AD deteriorate each other from the early stage of AD to the terminal stages of AD, focusing on the potential of different levels of nutritional factors, ranging from micronutrients to diet patterns. This review provides novel insights into reducing the risk of AD, delaying its progression, and improving prognosis. Highlights Two-fifths of Alzheimer's disease (AD) cases worldwide have been attributed to potentially modifiable risk factors. Up to approximate to 26% of community-dwelling patients with AD are malnourished, compared to 7%similar to 76% of institutionalized patients. Undernutrition effects the onset, progression, and prognosis of AD through multiple mechanisms. Various levels of nutritional supports were confirmed to be protective factors for AD via specific mechanisms.
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