Beautoide A, an Anti-Osteoclastogenic Sterol from Beauveria sp. NBUF147 Associated with an Irciniidae Sponge from the Marine Mesophotic Zone

被引：0

作者：

Ran, Guang-Jun ^{[1
]}

Wang, Ping ^{[1
]}

Wang, Hong-Kun ^{[1
]}

Wei, Ting-Ting ^{[1
]}

Liu, Yu-Ying ^{[1
]}

Jin, Hai-Xiao ^{[1
]}

Wang, Ting-Ting ^{[1
]}

He, Shan ^{[1
,2
]}

机构：

[1] Ningbo Univ, Li Dak Sum Yip Yio Chin Kenneth Li Marine Biophar, Hlth Sci Ctr, Ningbo 315211, Zhejiang, Peoples R China

[2] Peking Univ, Ningbo Inst Marine Med, Ningbo 315832, Zhejiang, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2024年 / 21卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Mesophotic coral ecosystems; Sponge-associated fungi; Beauveria sp; Sterol; Anti-osteoclastogenesis; NATURAL-PRODUCTS;

D O I：

10.1002/cbdv.202401689

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mesophotic coral ecosystems (MCEs), located at depths ranging from 30-150m, host some of the most diverse yet least explored marine bioresources, particularly significant for the discovery of new bioactive molecules. The fungus Beauveria sp. NBUF147, associated with an Irciniidae sponge from the mesophotic zone at a depth of 82m, underwent chemical investigation that led to the identification of one new sterol, beautoide A (1), and one reported sterol, 3 beta,5 alpha,9 alpha-trihydroxy-(22E,24R)-ergosta-7,22-dien-6-one (2). Their structures were determined from analysis of spectroscopic data and X-ray crystallography. Evaluation of biological activity in prednisolone-induced osteoporotic zebrafish showed that 1 was anti-osteoclastogenic invivo at 3.0 mu M.

引用

收藏

页数：5

相关论文

共 28 条

[1] Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidum [J].

Akihisa, Toshihiro ;

Nakamura, Yuji ;

Tagata, Masaaki ;

Tokuda, Harukuni ;

Yasukawa, Ken ;

Uchiyama, Emiko ;

Suzuki, Takashi ;

Kimura, Yumiko .

CHEMISTRY & BIODIVERSITY, 2007, 4 (02) :224-231

[2] Juvenile scleractinian assemblage and its association with adults and benthos at shallow and upper mesophotic depths in fringing and atoll reefs in the Philippines [J].

Albelda, Ritzelle L. ;

Cabaitan, Patrick C. ;

Sinniger, Frederic P. ;

Dumalagan, Edwin E., Jr. ;

Quimpo, Timothy Joseph R. ;

Olavides, Ronald Dionnie D. ;

Munar, Jeffrey C. ;

Villanoy, Cesar L. ;

Siringan, Fernando P. .

REGIONAL STUDIES IN MARINE SCIENCE, 2020, 40

[3] Marine Animal Microbiomes: Toward Understanding Host-Microbiome Interactions in a Changing Ocean [J].

Apprill, Amy .

FRONTIERS IN MARINE SCIENCE, 2017, 4

[4] Exploring the potential of marine natural products in drug development: A comprehensive review [J].

Banday, Abid H. ;

ul Azha, Noor ;

Farooq, Rehana ;

Sheikh, Sourab A. ;

Ganie, Muzafar A. ;

Parray, Mohammad N. ;

Mushtaq, Hina ;

Hameed, Iqra ;

Lone, Muzaffar A. .

PHYTOCHEMISTRY LETTERS, 2024, 59 :124-135

[5] Genomic, morphological, and physiological insights into coral acclimation along the depth gradient following an in situ reciprocal transplantation of planulae [J].

Bellworthy, Jessica ;

Scucchia, Federica ;

Goodbody-Gringley, Gretchen ;

Mass, Tali .

SCIENCE OF THE TOTAL ENVIRONMENT, 2024, 929

[6]

Bode HB, 2002, CHEMBIOCHEM, V3, P619, DOI 10.1002/1439-7633(20020703)3:7<619::AID-CBIC619>3.0.CO

[7]

2-9

[8] A new ecological index for the status of mesophotic megabenthic assemblages in the mediterranean based on ROV photography and video footage [J].

Canovas-Molina, Almudena ;

Montefalcone, Monica ;

Bavestrello, Giorgio ;

Cau, Angelo ;

Bianchi, Carlo Nike ;

Morri, Carla ;

Canese, Simonepietro ;

Bo, Marzia .

CONTINENTAL SHELF RESEARCH, 2016, 121 :13-20

[9] The interactive effects of ocean acidification and warming on bioeroding sponge Spheciospongia vesparium microbiome indicated by metatranscriptomics [J].

Chai, Guangjun ;

Li, Jinlong ;

Li, Zhiyong .

MICROBIOLOGICAL RESEARCH, 2024, 278

[10] Acremocholone, an Anti-Vibrio Steroid from the Marine Mesophotic Zone Ciocalypta Sponge-Associated Fungus Acremonium sp. NBUF150 [J].

Feng, Yun-Ping ;

Wang, Hong-Kun ;

Wu, Jia-Ling ;

Shao, Peng ;

Zhou, Wen-Li ;

Lai, Qi-Liang ;

Lin, Hou-Wen ;

Naman, C. Benjamin ;

Wang, Ting-Ting ;

He, Shan .

CHEMISTRY & BIODIVERSITY, 2022, 19 (04)