Prurigo nodularis and diffuse large B-cell lymphoma

Pruritic cutaneous lesions associated with lymphomas of the mediastinum may manifest several weeks or months before the onset of respiratory symptoms, underscoring the serious need for early detection. Identifying the primary thoracic cause carries particular clinical and therapeutic implications, as clinicians are not constantly searching for it. This article aims to provide a real-life case on this subject and invites clinicians to adopt a systematic approach when dealing with the symptoms of their patients. A chest radiograph is a low-cost, important imaging exam to investigate for a possible thoracic malignant cause of a chronic pruritus of unknown cause, which persists despite dermatological treatment.