Challenges and Emerging Strategies of Immunotherapy for Glioblastoma

被引：1

作者：

Mao, Mingchuan ^{[1
]}

Lei, Yao ^{[3
]}

Ma, Xianbin ^{[1
]}

Xie, Hai-Yan ^{[2
,3
]}

机构：

[1] Beijing Inst Technol, Sch Med Technol, Beijing 100081, Peoples R China

[2] Peking Univ, Chem Biol Ctr, Beijing 100191, Peoples R China

[3] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

CHEMBIOCHEM | 2025年 / 26卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Glioblastoma; Immunotherapy; Treatment Dilemma; Immunotherapy Strategy; TUMOR-ASSOCIATED MACROPHAGES; BLOOD-BRAIN-BARRIER; CANCER STEM-CELLS; GENE-THERAPY; T-CELLS; DENDRITIC CELLS; TISSUE FACTOR; RECURRENT GLIOBLASTOMA; CHECKPOINT BLOCKADE; TGF-BETA;

D O I：

10.1002/cbic.202400848

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glioblastoma (GBM) is recognized as the most lethal primary malignant tumor of the central nervous system. Although traditional treatments can somewhat prolong patient survival, the overall prognosis remains grim. Immunotherapy has become an effective method for GBM treatment. Oncolytic virus, checkpoint inhibitors, CAR T cells and tumor vaccines have all been applied in this field. Moreover, the combining of immunotherapy with traditional radiotherapy, chemotherapy, or gene therapy can further improve the treatment outcome. This review systematically summarizes the features of GBM, the recent progress of immunotherapy in overcoming GBM.

引用

页数：17

共 194 条

[1] The root of the problem [J].

Abbott, Alison .

NATURE, 2006, 442 (7104) :742-743

[2] Structure and function of the blood-brain barrier [J].

Abbott, N. Joan ;

Patabendige, Adjanie A. K. ;

Dolman, Diana E. M. ;

Yusof, Siti R. ;

Begley, David J. .

NEUROBIOLOGY OF DISEASE, 2010, 37 (01) :13-25

[3] Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma [J].

Agliardi, Giulia ;

Liuzzi, Anna Rita ;

Hotblack, Alastair ;

De Feo, Donatella ;

Nunez, Nicolas ;

Stowe, Cassandra L. ;

Friebel, Ekaterina ;

Nannini, Francesco ;

Rindlisbacher, Lukas ;

Roberts, Thomas A. ;

Ramasawmy, Rajiv ;

Williams, Iwan P. ;

Siow, Bernard M. ;

Lythgoe, Mark F. ;

Kalber, Tammy L. ;

Quezada, Sergio A. ;

Pule, Martin A. ;

Tugues, Sonia ;

Straathof, Karin ;

Becher, Burkhard .

NATURE COMMUNICATIONS, 2021, 12 (01)

[4] HER2-Specific Chimeric Antigen Receptor-Modified Virus-Specific T Cells for Progressive Glioblastoma A Phase 1 Dose-Escalation Trial [J].

Ahmed, Nabil ;

Brawley, Vita ;

Hegde, Meenakshi ;

Bielamowicz, Kevin ;

Kalra, Mamta ;

Landi, Daniel ;

Robertson, Catherine ;

Gray, Tara L. ;

Diouf, Oumar ;

Wakefield, Amanda ;

Ghazi, Alexia ;

Gerken, Claudia ;

Yi, Zhongzhen ;

Ashoori, Aidin ;

Wu, Meng-Fen ;

Liu, Hao ;

Rooney, Cliona ;

Dotti, Gianpietro ;

Gee, Adrian ;

Su, Jack ;

Kew, Yvonne ;

Baskin, David ;

Zhang, Yi Jonathan ;

New, Pamela ;

Grilley, Bambi ;

Stojakovic, Milica ;

Hicks, John ;

Powell, Suzanne Z. ;

Brenner, Malcolm K. ;

Heslop, Helen E. ;

Grossman, Robert ;

Wels, Winfried S. ;

Gottschalk, Stephen .

JAMA ONCOLOGY, 2017, 3 (08) :1094-1101

[5] Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma [J].

Ahmed, Nabil ;

Brawley, Vita S. ;

Hegde, Meenakshi ;

Robertson, Catherine ;

Ghazi, Alexia ;

Gerken, Claudia ;

Liu, Enli ;

Dakhova, Olga ;

Ashoori, Aidin ;

Corder, Amanda ;

Gray, Tara ;

Wu, Meng-Fen ;

Liu, Hao ;

Hicks, John ;

Rainusso, Nino ;

Dotti, Gianpietro ;

Mei, Zhuyong ;

Grilley, Bambi ;

Gee, Adrian ;

Rooney, Cliona M. ;

Brenner, Malcolm K. ;

Heslop, Helen E. ;

Wels, Winfried S. ;

Wang, Lisa L. ;

Anderson, Peter ;

Gottschalk, Stephen .

JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15) :1688-+

[6] Toll-like receptors: critical proteins linking innate and acquired immunity [J].

Akira, S ;

Takeda, K ;

Kaisho, T .

NATURE IMMUNOLOGY, 2001, 2 (08) :675-680

[7] Blood-brain barrier: emerging trends on transport models and new-age strategies for therapeutics intervention against neurological disorders [J].

Alajangi, Hema Kumari ;

Kaur, Mandeep ;

Sharma, Akanksha ;

Rana, Sumedh ;

Thakur, Shipali ;

Chatterjee, Mary ;

Singla, Neha ;

Jaiswal, Pradeep Kumar ;

Singh, Gurpal ;

Barnwal, Ravi Pratap .

MOLECULAR BRAIN, 2022, 15 (01)

[8] Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas [J].

Amoozgar, Zohreh ;

Kloepper, Jonas ;

Ren, Jun ;

Tay, Rong En ;

Kazer, Samuel W. ;

Kiner, Evgeny ;

Krishnan, Shanmugarajan ;

Posada, Jessica M. ;

Ghosh, Mitrajit ;

Mamessier, Emilie ;

Wong, Christina ;

Ferraro, Gino B. ;

Batista, Ana ;

Wang, Nancy ;

Badeaux, Mark ;

Roberge, Sylvie ;

Xu, Lei ;

Huang, Peigen ;

Shalek, Alex K. ;

Fukumura, Dai ;

Kim, Hye-Jung ;

Jain, Rakesh K. .

NATURE COMMUNICATIONS, 2021, 12 (01)

[9] Glial and myeloid heterogeneity in the brain tumour microenvironment [J].

Andersen, Brian M. ;

Akl, Camilo Faust ;

Wheeler, Michael A. ;

Chiocca, E. Antonio ;

Reardon, David A. ;

Quintana, Francisco J. .

NATURE REVIEWS CANCER, 2021, 21 (12) :786-802

[10] Hematopoietic stem cell gene therapy targeting TGFβ enhances the efficacy of irradiation therapy in a preclinical glioblastoma model [J].

Andreou, Tereza ;

Williams, Jennifer ;

Brownlie, Rebecca J. ;

Salmond, Robert J. ;

Watson, Erica ;

Shaw, Gary ;

Melcher, Alan ;

Wurdak, Heiko ;

Short, Susan C. ;

Lorger, Mihaela .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 (03)

← 1 2 3 4 5 6 7 8 9 10 →