Impact of gut microbiome on immunotherapy resistance in hepatocellular carcinoma: a review article

被引：0
作者：
Shah, Aun R. [1 ]
Mukherjee, Sandeep [1 ]
机构：
[1] Creighton Univ, Med Ctr, Div Gastroenterol & Hepatol, Educ Bldg,Suite 401,7710 Mercy Rd, Omaha, NE 68124 USA
来源：
HEPATOMA RESEARCH | 2024年 / 10卷
关键词：
Hepatocellular carcinoma; HCC; immunotherapy; microbiota; microbiome; THERAPY; EPIDEMIOLOGY; EFFICACY; CANCER;
D O I：
10.20517/2394-5079.2024.76
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This article reviews the interactions between gut microbiota and cancer immunotherapies and discusses microbiota-based patient stratification strategies such as the prediction of response and the early recognition of toxic events. Additionally, it explores the emerging potential of microbiotherapy to enhance anti-neoplastic efficacy and alleviate toxicity, with the ultimate goal of developing personalized treatment regimens for patients with hepatocellular carcinoma (HCC).
引用
收藏
页数：12
相关论文
共 42 条
[1]  
Asrani S.K., 2019, Burden of liver diseases in the world, V70, P151
[2]   The Gut Microbiome, Aging, and Longevity: A Systematic Review [J].
Badal, Varsha D. ;
Vaccariello, Eleonora D. ;
Murray, Emily R. ;
Yu, Kasey E. ;
Knight, Rob ;
Jeste, Dilip V. ;
Nguyen, Tanya T. .
NUTRIENTS, 2020, 12 (12) :1-25
[3]   Prognostic factors and predictors of sorafenib benefit in patients with hepatocellular carcinoma: Analysis of two phase III studies [J].
Bruix, Jordi ;
Cheng, Ann-Lii ;
Meinhardt, Gerold ;
Nakajima, Keiko ;
De Sanctis, Yoriko ;
Llovet, Josep .
JOURNAL OF HEPATOLOGY, 2017, 67 (05) :999-1008
[4]   Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice [J].
Cani, Patrice D. ;
Bibiloni, Rodrigo ;
Knauf, Claude ;
Neyrinck, Audrey M. ;
Neyrinck, Audrey M. ;
Delzenne, Nathalle M. ;
Burcelin, Remy .
DIABETES, 2008, 57 (06) :1470-1481
[5]   Composition, variability, and temporal stability of the intestinal microbiota of the elderly [J].
Claesson, Marcus J. ;
Cusack, Siobhan ;
O'Sullivan, Orla ;
Greene-Diniz, Rachel ;
de Weerd, Heleen ;
Flannery, Edel ;
Marchesi, Julian R. ;
Falush, Daniel ;
Dinan, Timothy ;
Fitzgerald, Gerald ;
Stanton, Catherine ;
van Sinderen, Douwe ;
O'Connor, Michael ;
Harnedy, Norma ;
O'Connor, Kieran ;
Henry, Colm ;
O'Mahony, Denis ;
Fitzgerald, Anthony P. ;
Shanahan, Fergus ;
Twomey, Cillian ;
Hill, Colin ;
Ross, R. Paul ;
O'Toole, Paul W. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 :4586-4591
[6]   Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients [J].
Davar, Diwakar ;
Dzutsev, Amiran K. ;
McCulloch, John A. ;
Rodrigues, Richard R. ;
Chauvin, Joe-Marc ;
Morrison, Robert M. ;
Deblasio, Richelle N. ;
Menna, Carmine ;
Ding, Quanquan ;
Pagliano, Ornella ;
Zidi, Bochra ;
Zhang, Shuowen ;
Badger, Jonathan H. ;
Vetizou, Marie ;
Cole, Alicia M. ;
Fernandes, Miriam R. ;
Prescott, Stephanie ;
Costa, Raquel G. F. ;
Balaji, Ascharya K. ;
Morgun, Andrey ;
Vujkovic-Cvijin, Ivan ;
Wang, Hong ;
Borhani, Amir A. ;
Schwartz, Marc B. ;
Dubner, Howard M. ;
Ernst, Scarlett J. ;
Rose, Amy ;
Najjar, Yana G. ;
Belkaid, Yasmine ;
Kirkwood, John M. ;
Trinchieri, Giorgio ;
Zarour, Hassane M. .
SCIENCE, 2021, 371 (6529) :595-+
[7]   Influence of Probiotics Administration Before Liver Resection in Patients with Liver Disease: A Randomized Controlled Trial [J].
Edouard, Roussel ;
Carole, Brasse-Lagnel ;
Jean-Jacques, Tuech ;
Helene, Montialoux ;
Eloise, Papet ;
Pauline, Tortajada ;
Soumeya, Bekri ;
Lilian, Schwarz .
WORLD JOURNAL OF SURGERY, 2022, 46 (03) :656-665
[8]   Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial [J].
El-Khoueiry, Anthony B. ;
Sangro, Bruno ;
Yau, Thomas ;
Crocenzi, Todd S. ;
Kudo, Masatoshi ;
Hsu, Chiun ;
Kim, Tae-You ;
Choo, Su-Pin ;
Trojan, Jorg ;
Welling, Theodore H., III ;
Meyer, Tim ;
Kang, Yoon-Koo ;
Yeo, Winnie ;
Chopra, Akhil ;
Anderson, Jeffrey ;
dela Cruz, Christine ;
Lang, Lixin ;
Neely, Jaclyn ;
Tang, Hao ;
Dastani, Homa B. ;
Melero, Ignacio .
LANCET, 2017, 389 (10088) :2492-2502
[9]   Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis [J].
El-Serag, Hashem B. ;
Rudolph, Lenhard .
GASTROENTEROLOGY, 2007, 132 (07) :2557-2576
[10]   Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma [J].
Finn, Richard S. ;
Qin, Shukui ;
Ikeda, Masafumi ;
Galle, Peter R. ;
Ducreux, Michel ;
Kim, Tae-You ;
Kudo, Masatoshi ;
Breder, Valeriy ;
Merle, Philippe ;
Kaseb, Ahmed O. ;
Li, Daneng ;
Verret, Wendy ;
Xu, Derek-Zhen ;
Hernandez, Sairy ;
Liu, Juan ;
Huang, Chen ;
Mulla, Sohail ;
Wang, Yulei ;
Lim, Ho Yeong ;
Zhu, Andrew X. ;
Cheng, Ann-Lii .
NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (20) :1894-1905
12345