Infection control rate in two-stage exchange for chronic periprosthetic joint infection: a retrospective cohort study focusing on antibiotic-free period

被引：0
作者：
Haiqi Ding [1 ]
Xuhui Yuan [2 ]
Yang Chen [3 ]
Changyu Huang [1 ]
Hongxin Hu [2 ]
Yufeng Guo [3 ]
Chengguo Huang [1 ]
Xinyu Fang [2 ]
Wenming Zhang [3 ]
机构：
[1] Department of Orthopaedic Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou
[2] Department of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou
[3] Fujian Provincial Institute of Orthopedics, the First Affiliated Hospital, Fujian Medical University, Fuzhou
[4] Department of Orthopedic Surgery, Affiliated Hospital of Putian University, Putian
[5] Department of Orthopaedic Surgery, Changtai County Hospital, Zhangzhou
[6] Department of Orthopaedic Surgery, Pingnan County Hospital, Ningde
来源：
BMC Infectious Diseases | / 25卷 / 1期
关键词：
Antibiotic holiday; Articulating spacer; Infection control rate; Periprosthetic joint infection; Two-stage exchange;
D O I：
10.1186/s12879-025-10919-1
中图分类号：
学科分类号：
摘要：
Background: Limited information is available regarding the impact of antibiotic holidays on the infection control rate of two-stage revisions for chronic periprosthetic joint infection (PJI). This study aims to evaluate the impact of an antibiotic holiday on the infection control rate after two-stage exchange for PJI. Methods: We retrospectively analyzed data from patients with chronic PJI who underwent long-interval two-stage exchange using joint spacers at our center from June 2012 to June 2021. Patients were divided into Short Antibiotic Holiday (SAH, antibiotic holiday < 3 months) and Long Antibiotic Holiday (LAH, antibiotic holiday ≥ 3 months) groups. Following completion of the two-stage exchange treatment, patients were monitored for a minimum of 2 years to determine the infection control rate. Results: A total of 75 chronic PJI patients were included, comprising 42 hip and 33 knee cases. In chronic PJI of the hip, the LAH group demonstrated a significantly higher infection control rate compared to the SAH group (27/27 vs 12/15, p = 0.016). For chronic PJI of the knee, the infection control rate in the LAH group was comparable to that in the SAH group (20/21 vs 10/12, p = 0.238). Furthermore, no significant differences in clinical outcomes were observed between the LAH and SAH groups. Conclusions: A ≥ 3-month antibiotic holiday, without compromising postoperative functional recovery, may enhance infection control rates after two-stage exchange for chronic hip PJI using joint spacers. © The Author(s) 2025.
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