Retro-orbital Metastasis in Chromophobe Renal Cell Carcinoma: A Case Report and Review

被引：0
作者：
Kapagan, Tanju [1 ]
Bulut, Nilufer [1 ]
Halici, Mehmet [2 ]
Erdem, Gokmen Umut [1 ]
机构：
[1] Basaksehir Cam & Sakura City Hosp, Dept Med Oncol, TR-34480 Istanbul, Turkiye
[2] Basaksehir Cam & Sakura City Hosp, Dept Radiat Oncol, TR-34480 Istanbul, Turkiye
来源：
ARCHIVES OF IRANIAN MEDICINE | 2025年 / 28卷 / 03期
关键词：
Cancer; Chromophobe renal cell carcinoma; Palliative radiotherapy; Retro-orbital metastasis; MULTICENTER;
D O I：
10.34172/aim.31231
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Chromophobe renal cell carcinoma (ChRCC) is a rare subtype of renal cell carcinoma (RCC). We present a case of a 61-year-old male with ChRCC who exhibited unusual metastasis to the retro-orbital area, a site rarely affected by RCC. The patient experienced diplopia and proptosis, prompting treatment with sunitinib and palliative radiotherapy. Remarkably, rapid improvement in ocular symptoms was observed following radiotherapy. Despite this localized response, the patient's overall condition deteriorated, highlighting the aggressive nature of ChRCC. This case underscores the importance of considering ChRCC in metastatic presentations and the potential efficacy of local palliative interventions.
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收藏
页码：171 / 173
页数：3
相关论文
共 20 条
[1]   Orbital Metastases: When to Suspect? When to Biopsy? [J].
Allen, Richard Cutler .
MIDDLE EAST AFRICAN JOURNAL OF OPHTHALMOLOGY, 2018, 25 (02) :60-64
[2]   Chromophobe Renal Cell Carcinoma: Histomorphologic Characteristics and Evaluation of Conventional Pathologic Prognostic Parameters in 145 Cases [J].
Amin, Mahul B. ;
Paner, Gladell P. ;
Alvarado-Cabrero, Isabel ;
Young, Andrew N. ;
Stricker, Hans J. ;
Lyles, Robert H. ;
Moch, Holger .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2008, 32 (12) :1822-1834
[3]   Everolimus versus sunitinib for patients with metastatic non-clear-cell renal cell carcinoma (ASPEN): a multicentre, open-label, randomised phase 2 trial [J].
Armstrong, Andrew J. ;
Halabi, Susan ;
Eisen, Tim ;
Broderick, Samuel ;
Stadler, Walter M. ;
Jones, Robert J. ;
Garcia, Jorge A. ;
Vaishampayan, Ulka N. ;
Picus, Joel ;
Hawkins, Robert E. ;
Hainsworth, John D. ;
Kollmannsberger, Christian K. ;
Logan, Theodore F. ;
Puzanov, Igor ;
Pickering, Lisa M. ;
Ryan, Christopher W. ;
Protheroe, Andrew ;
Lusk, Christine M. ;
Oberg, Sadie ;
George, Daniel J. .
LANCET ONCOLOGY, 2016, 17 (03) :378-388
[4]   Effect of papillary and chromophobe cell type on disease-free survival after nephrectomy for renal cell carcinoma [J].
Beck, SDW ;
Patel, MI ;
Snyder, ME ;
Kattan, MW ;
Motzer, RJ ;
Reuter, VE ;
Russo, P .
ANNALS OF SURGICAL ONCOLOGY, 2004, 11 (01) :71-77
[5]   Palliative radiation therapy for patients with orbital and ocular metastases [J].
Chik, Jeannie Y. K. ;
Leung, Carmen W. L. ;
Wong, Kam Hung .
ANNALS OF PALLIATIVE MEDICINE, 2020, 9 (06) :4458-4466
[6]   Chromophobe renal cell carcinoma: Comprehensive analysis of 104 cases from multicenter European database [J].
Cindolo, L ;
De la Taille, A ;
Schips, L ;
Zigeuner, RE ;
Ficarra, V ;
Tostain, J ;
Artibani, W ;
Gallo, A ;
Salzano, L ;
Patard, JJ .
UROLOGY, 2005, 65 (04) :681-686
[7]   Evaluation of Clear Cell, Papillary, and Chromophobe Renal Cell Carcinoma Metastasis Sites and Association With Survival [J].
Dudani, Shaan ;
de Velasco, Guillermo ;
Wells, J. Connor ;
Gan, Chun Loo ;
Donskov, Frede ;
Porta, Camillo ;
Fraccon, Anna ;
Pasini, Felice ;
Lee, Jae Lyun ;
Hansen, Aaron ;
Bjarnason, Georg A. ;
Beuselinck, Benoit ;
Pal, Sumanta K. ;
Yuasa, Takeshi ;
Kroeger, Nils ;
Kanesvaran, Ravindran ;
Reaume, M. Neil ;
Canil, Christina ;
Choueiri, Toni K. ;
Heng, Daniel Y. C. .
JAMA NETWORK OPEN, 2021, 4 (01)
[8]   Chromophobe renal cell carcinoma-diagnosis and prognosis [J].
Erlmeier, F. .
PATHOLOGE, 2019, 40 (Suppl 3) :S252-S258
[9]   Outcome of Patients With Metastatic Chromophobe Renal Cell Carcinoma Treated With Sunitinib [J].
Keizman, Daniel ;
Sarid, David ;
Lee, Jae L. ;
Sella, Avishay ;
Gottfried, Maya ;
Hammers, Hans ;
Eisenberger, Mario A. ;
Carducci, Michael A. ;
Sinibaldi, Victoria ;
Neiman, Victoria ;
Rosenbaum, Eli ;
Peer, Avivit ;
Neumann, Avivit ;
Mermershtain, Wilmosh ;
Rouvinov, Keren ;
Berger, Raanan ;
Yildiz, Ibrahim .
ONCOLOGIST, 2016, 21 (10) :1212-1217
[10]   Pathobiology and prognosis of chromophobe renal cell carcinoma [J].
Klatte, Tobias ;
Han, Ken-ryu ;
Said, Jonathan W. ;
Boehm, Malte ;
Allhoff, Ernst Peter ;
Kabbinavar, Fairooz F. ;
Belldegrun, Arie S. ;
Pantuck, Allan J. .
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2008, 26 (06) :604-609
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