Longitudinal changes in white matter free water in cerebral small vessel disease: Relationship to cerebral blood flow and white matter fiber alterations

被引：1

作者：

Lin, Miao ^{[1
]}

Wang, Shuyue ^{[1
]}

Hong, Hui ^{[1
]}

Zhang, Yao ^{[1
]}

Xie, Linyun ^{[1
]}

Cui, Lei ^{[1
]}

Liu, Lingyun ^{[1
]}

Jiaerken, Yeerfan ^{[1
]}

Yu, Xinfeng ^{[1
]}

Zhang, Minming ^{[1
]}

De Luca, Alberto ^{[2
,3
]}

Zhang, Ruiting ^{[1
]}

Huang, Peiyu ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Radiol, 8 Jiefang Rd, Hangzhou 310009, Peoples R China

[2] Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Neurol & Neurosurg, Utrecht, Netherlands

[3] Univ Med Ctr Utrecht, Image Sci Inst, Utrecht, Netherlands

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2025年 / 45卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Cerebral small vessel disease; white matter; free water; diffusion-tensor imaging; cerebral blood flow; DENSITY; MRI;

D O I：

10.1177/0271678X241305480

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

White matter (WM) free water (FW) is a potential imaging marker for cerebral small vessel disease (CSVD). This study aimed to characterize longitudinal changes in WM FW and investigate factors contributing to its elevation in CSVD. We included 80 CSVD patients and 40 normal controls (NCs) with multi-modality MRI data. Cerebral blood flow (CBF) was measured, and fiber alterations were assessed using total apparent fiber density (AFDt). FW were extracted from whole WM, white matter hyperintensities (WMH) and normal-appearing WM (NAWM). Baseline and longitudinal FW elevation were compared between patients and NCs, and between WMH and NAWM. We investigated whether baseline vascular risk factor score, CBF, and AFDt could predict longitudinal FW elevation. Association between cognition and WM FW in CSVD was also assessed. Results shown that FW was higher and increased faster in CSVD compared to NCs and in WMH compared to NAWM. Baseline AFDt predicted longitudinal FW elevation in CSVD patients, while CBF predicted FW changes only in controls. WM FW was associated with cognitive impairment. These findings suggest that CSVD is associated with a faster increase in WM FW. Hypoperfusion and WM fiber alterations might accelerate FW elevation, which is associated with cognitive decline.

引用

页码：932 / 944

页数：13

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