Nanoparticles Modulating the Immune Microenvironment in Breast Cancer Treatment

被引：1

作者：

Guo, Li-Juan ^{[1
]}

Wu, Jinsheng ^{[1
]}

Lu, Weifeng ^{[2
]}

Li, Jing ^{[1
]}

Wang, Yeling ^{[1
]}

Yang, Hui ^{[1
]}

Wang, Tian-Zhu ^{[3
]}

机构：

[1] Hainan Med Univ, Dept Radiotherapy, Affiliated Hosp 1, Haikou 570102, Peoples R China

[2] Hainan Med Coll, Affiliated Hosp 1, Inst Oncol, Haikou 570102, Peoples R China

[3] Hainan Canc Hosp, Dept Radiat Oncol, Haikou 570311, Peoples R China

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2025年 / 20卷

关键词：

nanoparticle; breast cancer; immune cells; CELLS; MACROPHAGES; SUPPRESSION; DEPLETION; DELIVERY; DRUG;

D O I：

10.2147/IJN.S492713

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Breast cancer remains a significant therapeutic challenge, with the immune microenvironment playing a crucial role in its progression and treatment response. This review investigates the potential of nanoparticles to modulate the immune microenvironment in breast cancer therapy. Initially, we discuss the composition and influence of the immune microenvironment on breast cancer, followed by current strategies targeting these components. We then provide strategies of nanoparticles for targeting immune cells such as macrophages, dendritic cells, and T-cells. The role of nanoparticles in enhancing immune checkpoint blockade (ICB) and their application in cancer vaccines is also examined. Additionally, we explore the synergistic effects of combining nanoparticles with conventional therapies. The review addresses the challenges in clinical translation, focusing on safety, biocompatibility, and toxicity. Finally, we outline future research directions and the potential advancements in nanoparticle-based immunotherapy, emphasizing their transformative impact on breast cancer treatment.

引用

页码：1367 / 1382

页数：16

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