Diterpenoids and lignans from the stems of Tripterygium wilfordii and their anti-inflammatory activities

被引：2

作者：

Tian, Yulu ^{[1
]}

Wei, Yazi ^{[1
]}

Luo, Haowen ^{[1
]}

Chen, Xinyi ^{[1
]}

Ma, Jie ^{[1
]}

Zang, Yingda ^{[1
]}

Zhang, Tiantai ^{[1
]}

Zhang, Dongming ^{[1
]}

Li, Chuangjun ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China

来源：

FITOTERAPIA | 2025年 / 180卷

关键词：

Tripterygium wilfordii; Stem; Diterpenoids; Lignans; Anti-inflammatory; IMMUNOSUPPRESSIVE TERPENOIDS; NEOLIGNANS; TRIPTOLIDE; LEAVES;

D O I：

10.1016/j.fitote.2024.106306

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two undescribed diterpenoids (1-2) and three lignans (3a/3b, 4a), together with sixteen known compounds (4b, 5-9, 10a/10b-14a/14b) were obtained from the stems of Tripterygium wilfordii (T. wilfordii). The structures of these new compounds were elucidated by detailed spectroscopic analyses, and their absolute configurations were estabished by ECD calculations. Some compounds exhibited moderate inhibitory activities against IL-6 production in LPS-stimulated RAW 264.7 macrophages in vitro. Compound 5 showed significant anti-inflammatory activity in vitro (IC50, 0.77 mu M) and inhibited macrophage polarization towards a pro-inflammatory phenotype.

引用

页数：9

共 28 条

[21] Triptolide inhibits cell growth and inflammatory response of fibroblast-like synoviocytes by modulating hsa-circ-0003353/microRNA-31-5p/CDK1 axis in rheumatoid arthritis [J].

Wen, Jian-ting ;

Liu, Jian ;

Wan, Lei ;

Xin, Ling ;

Guo, Jin-chen ;

Sun, Yan-qiu ;

Wang, Xin ;

Wang, Jie .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2022, 106

[22] Three new sesquiterpene alkaloids from the root of Tripterygium wilfordii [J].

Wu, Chun Min ;

Zhou, Lin Mei ;

Chai, Yi Feng ;

Wu, Yu Tian ;

Fan, Guo Rong .

CHINESE CHEMICAL LETTERS, 2010, 21 (07) :830-833

[23] Lignans and Neolignans from Sinocalamus affinis and Their Absolute Configurations [J].

Xiong, Liang ;

Zhu, Chenggeng ;

Li, Yanru ;

Tian, Ye ;

Lin, Sheng ;

Yuan, Shaopeng ;

Hu, Jinfeng ;

Hou, Qi ;

Chen, Naihong ;

Yang, Yongchun ;

Shi, Jiangong .

JOURNAL OF NATURAL PRODUCTS, 2011, 74 (05) :1188-1200

[24] Bioactive compounds from Peperomia pellucida [J].

Xu, S ;

Li, N ;

Ning, MM ;

Zhou, CH ;

Yang, QR ;

Wang, MW .

JOURNAL OF NATURAL PRODUCTS, 2006, 69 (02) :247-250

[25]

YAMAZAKI M, 1994, BIOL PHARM BULL, V17, P1604, DOI 10.1248/bpb.17.1604

[26] Coumarinolignoids and lignanoids from the stems and leaves of Sapium discolor [J].

Zhang, Yong-Li ;

Pan, Qi-Min ;

Liao, Hai-Bing ;

Qin, Jiang-Ke ;

Li, Ning ;

Liang, Dong ;

Zhang, Gui-Jie .

FITOTERAPIA, 2019, 133 :17-22

[27] Phenylpropanoid and lignan glycosides from the aerial parts of Lespedeza cuneata [J].

Zhou, Jian ;

Li, Chuang-Jun ;

Yang, Jing-Zhi ;

Ma, Jie ;

Wu, Lian-Qiu ;

Wang, Wen-Jie ;

Zhang, Dong-Ming .

PHYTOCHEMISTRY, 2016, 121 :58-64

[28] Enantiomeric neolignans and sesquineolignans from Jatropha integerrima and their absolute configurations [J].

Zhu, Jian-Yong ;

Cheng, Bao ;

Zheng, Yin-Jia ;

Dong, Zhen ;

Lin, Shu-Ling ;

Tang, Gui-Hua ;

Gu, Qiong ;

Yin, Sheng .

RSC ADVANCES, 2015, 5 (16) :12202-12208

← 1 2 3 →