Diterpenoids and lignans from the stems of Tripterygium wilfordii and their anti-inflammatory activities

被引：1

作者：

Tian, Yulu ^{[1
]}

Wei, Yazi ^{[1
]}

Luo, Haowen ^{[1
]}

Chen, Xinyi ^{[1
]}

Ma, Jie ^{[1
]}

Zang, Yingda ^{[1
]}

Zhang, Tiantai ^{[1
]}

Zhang, Dongming ^{[1
]}

Li, Chuangjun ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China

来源：

FITOTERAPIA | 2025年 / 180卷

关键词：

Tripterygium wilfordii; Stem; Diterpenoids; Lignans; Anti-inflammatory; IMMUNOSUPPRESSIVE TERPENOIDS; NEOLIGNANS; TRIPTOLIDE; LEAVES;

D O I：

10.1016/j.fitote.2024.106306

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two undescribed diterpenoids (1-2) and three lignans (3a/3b, 4a), together with sixteen known compounds (4b, 5-9, 10a/10b-14a/14b) were obtained from the stems of Tripterygium wilfordii (T. wilfordii). The structures of these new compounds were elucidated by detailed spectroscopic analyses, and their absolute configurations were estabished by ECD calculations. Some compounds exhibited moderate inhibitory activities against IL-6 production in LPS-stimulated RAW 264.7 macrophages in vitro. Compound 5 showed significant anti-inflammatory activity in vitro (IC50, 0.77 mu M) and inhibited macrophage polarization towards a pro-inflammatory phenotype.

引用

页数：9

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