Molecular biology: In competition, actin filament turnover saves the day

被引：0

作者：

Suarez, Cristian ^{[1
]}

Kovar, David R. ^{[1
,2
]}

机构：

[1] Univ Chicago, Dept Mol Genet & Cell Biol, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Biochem & Mol Biol, Chicago, IL 60637 USA

来源：

CURRENT BIOLOGY | 2025年 / 35卷 / 03期

关键词：

ARP2/3; COMPLEX; SIZE;

D O I：

10.1016/j.cub.2024.12.036

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cellular actin cytoskeleton networks compete for limited actin monomers. New in vitro reconstitutions with purified proteins reveal that without network turnover, the strongest networks monopolize all the resources. However, with turnover, weaker networks survive and coexist with stronger networks.

引用

页码：R101 / R104

页数：4

共 14 条

[1] Homeostatic Actin Cytoskeleton Networks Are Regulated by Assembly Factor Competition for Monomers [J].

Burke, Thomas A. ;

Christensen, Jenna R. ;

Barone, Elisabeth ;

Suarez, Cristian ;

Sirotkin, Vladimir ;

Kovar, David R. .

CURRENT BIOLOGY, 2014, 24 (05) :579-585

[2] How Cells Know the Size of Their Organelles [J].

Chan, Yee-Hung M. ;

Marshall, Wallace F. .

SCIENCE, 2012, 337 (6099) :1186-1189

[3] Organelle Growth Control through Limiting Pools of Cytoplasmic Components [J].

Goehring, Nathan W. ;

Hyman, Anthony A. .

CURRENT BIOLOGY, 2012, 22 (09) :R330-R339

[4] Mechanisms of actin disassembly and turnover [J].

Goode, Bruce L. ;

Eskin, Julian ;

Shekhar, Shashank .

JOURNAL OF CELL BIOLOGY, 2023, 222 (12)

[5] Balancing limited resources in actin network competition [J].

Guerin, Christophe ;

N'Diaye, Anne-Betty ;

Gressin, Laurene ;

Mogilner, Alex ;

Thery, Manuel ;

Blanchoin, Laurent ;

Colin, Alexandra .

CURRENT BIOLOGY, 2025, 35 (03) :500-513.e5

[6] Arp2/3 complex ATP hydrolysis promotes lamellipodial actin network disassembly but is dispensable for assembly [J].

Ingerman, Elena ;

Hsiao, Jennifer Ying ;

Mullins, R. Dyche .

JOURNAL OF CELL BIOLOGY, 2013, 200 (05) :619-633

[7] F-Actin Cytoskeleton Network Self-Organization Through Competition and Cooperation [J].

Kadzik, Rachel S. ;

Homa, Kaitlin E. ;

Kovar, David R. .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 36, 2020, 2020, 36 :35-60

[8] Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin [J].

Koestler, Stefan A. ;

Steffen, Anika ;

Nemethova, Maria ;

Winterhoff, Moritz ;

Luo, Ningning ;

Holleboom, J. Margit ;

Krupp, Jessica ;

Jacob, Sonja ;

Vinzenz, Marlene ;

Schur, Florian ;

Schlueter, Kai ;

Gunning, Peter W. ;

Winkler, Christoph ;

Schmeiser, Christian ;

Faix, Jan ;

Stradal, Theresia E. B. ;

Small, J. Victor ;

Rottner, Klemens .

MOLECULAR BIOLOGY OF THE CELL, 2013, 24 (18) :2861-2875

[9] Reconstitution of actin-based motility of Listeria and Shigella using pure proteins [J].

Loisel, TP ;

Boujemaa, R ;

Pantaloni, D ;

Carlier, MF .

NATURE, 1999, 401 (6753) :613-616

[10] Regulation of the formin for3p by cdc42p and bud6p [J].

Martin, Sophie G. ;

Rincon, Sergio A. ;

Basu, Roshni ;

Perez, Pilar ;

Chang, Fred .

MOLECULAR BIOLOGY OF THE CELL, 2007, 18 (10) :4155-4167

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