Lasting effects of adolescent social instability stress on dendritic morphology in the nucleus accumbens in female and male Long Evans rats

被引：1
作者：
Patel, Ashutosh [1 ,4 ]
Aljaabary, Abdulhai [2 ,3 ]
Yuan, YiJie [2 ,3 ]
Asgari, Pardis [2 ,3 ]
Bailey, Craig D. C. [4 ]
McCormick, Cheryl M. [2 ,3 ]
机构：
[1] Univ Toronto Scarborough, Dept Psychol, 1265 Mil Trail, Toronto, ON M1C 1A4, Canada
[2] Brock Univ, Dept Psychol, 1812 Sir Isaac Brock Way, St Catharines, ON L2S 3A1, Canada
[3] Brock Univ, Ctr Neurosci, 1812 Sir Isaac Brock Way, St Catharines, ON L2S 3A1, Canada
[4] Univ Guelph, Dept Biomed Sci, 50 Stone Rd East, Guelph, ON N1G 2W1, Canada
来源：
NEUROTOXICOLOGY AND TERATOLOGY | 2024年 / 106卷
基金：
加拿大自然科学与工程研究理事会; 加拿大创新基金会;
关键词：
Nucleus accumbens; Social instability; Adolescence; Dendritic spines; Dendritic structure; Plasticity; MEDIAL PREFRONTAL CORTEX; BRAIN MATURATION; BASOLATERAL AMYGDALA; ADULTHOOD; DOPAMINE; NEURONS; SPINES; SHELL; CORE; AMPHETAMINE;
D O I：
10.1016/j.ntt.2024.107401
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Social instability stress (SS) in adolescence in rats leads to long-lasting changes in social behaviour and rewardrelated behaviour relative to control rats. Given the role of the nucleus accumbens (NAc) in such behaviours, we investigated the morphology of medium spiny neurons (MSNs), which are most neurons in the NAc, in adult female and male rats exposed to SS in adolescence. Irrespective of sex, SS rats had increased number of dendritic spines in both the core and shell regions of the NAc (2.3 % and 18.1 % increase, respectively). In the core, SS rats had a 16 % reduction in the total dendritic lengths of MSNs, whereas in the shell, SS rats had a greater dendritic length closer to the soma, and particularly in SS female rats, whereas the opposite was found farther from the soma (SS 10.6 % > CTL overall). Although the extent to which such structural changes may underlie the enduring effects of SS in adolescence requires investigation, the results add to evidence that changes to the social environment in adolescence can determine adult neuronal structural.
引用
收藏
页数：9
相关论文
共 66 条
[1]   Social Instability Stress in Adolescence and Social Interaction in Female Rats [J].
Asgari, Pardis ;
McKinney, Ghraer ;
Hodgesb, Travis E. ;
McCormick, Cheryl M. .
NEUROSCIENCE, 2021, 477 :1-13
[2]   Early Social Experience Is Critical for the Development of Cognitive Control and Dopamine Modulation of Prefrontal Cortex Function [J].
Baarendse, Petra J. J. ;
Counotte, Danielle S. ;
O'Donnell, Patricio ;
Vanderschuren, Louk J. M. J. .
NEUROPSYCHOPHARMACOLOGY, 2013, 38 (08) :1485-1494
[3]   Juvenile peer play experience and the development of the orbitofrontal and medial prefrontal cortices [J].
Bell, Heather C. ;
Pellis, Sergio M. ;
Kolb, Bryan .
BEHAVIOURAL BRAIN RESEARCH, 2010, 207 (01) :7-13
[4]   SUB-CHRONIC VARIABLE STRESS INDUCES SEX-SPECIFIC EFFECTS ON GLUTAMATERGIC SYNAPSES IN THE NUCLEUS ACCUMBENS [J].
Brancato, Anna ;
Bregman, Dana ;
Ahn, H. Francisica ;
Pfau, Madeline L. ;
Menard, Caroline ;
Cannizzaro, Carla ;
Russo, Scott J. ;
Hodes, Georgia E. .
NEUROSCIENCE, 2017, 350 :180-189
[5]   Social instability in adolescence differentially alters dendritic morphology in the medial prefrontal cortex and its response to stress in adult male and female rats [J].
Breach, Michaela R. ;
Moench, Kelly M. ;
Wellman, Cara L. .
DEVELOPMENTAL NEUROBIOLOGY, 2019, 79 (9-10) :839-856
[6]   Separable Roles of the Nucleus Accumbens Core and Shell in Context- and Cue-Induced Alcohol-Seeking [J].
Chaudhri, Nadia ;
Sahuque, Lacey L. ;
Schairer, William W. ;
Janak, Patricia H. .
NEUROPSYCHOPHARMACOLOGY, 2010, 35 (03) :783-791
[7]   Dopamine Axon Targeting in the Nucleus Accumbens in Adolescence Requires Netrin-1 [J].
Cuesta, Santiago ;
Nouel, Dominique ;
Reynolds, Lauren M. ;
Morgunova, Alice ;
Torres-Berrio, Angelica ;
White, Amanda ;
Hernandez, Giovanni ;
Cooper, Helen M. ;
Flores, Cecilia .
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, 8
[8]   Adolescent Social Instability Stress Increases Aggression in a Food Competition Task in Adult Male Long-Evans Rats [J].
Cumming, Mark J. ;
Thompson, Madison A. ;
McCormick, Cheryl M. .
DEVELOPMENTAL PSYCHOBIOLOGY, 2014, 56 (07) :1575-1588
[9]   Mapping subcortical brain maturation during adolescence: evidence of hemisphere- and sex-specific longitudinal changes [J].
Dennison, Meg ;
Whittle, Sarah ;
Yuecel, Murat ;
Vijayakumar, Nandita ;
Kline, Alexandria ;
Simmons, Julian ;
Allen, Nicholas B. .
DEVELOPMENTAL SCIENCE, 2013, 16 (05) :772-791
[10]   Nucleus accumbens shell and core dopamine: differential role in behavior and addiction [J].
Di Chiara, G .
BEHAVIOURAL BRAIN RESEARCH, 2002, 137 (1-2) :75-114
1234567