CRISPR-Based Functional Genomics Studies Identify Mechanisms of Multiple Myeloma (MM) Cell Response to vs. Resistance Against Novel Pharmacological Mutant-Specific KRAS Inhibitors

被引：0

作者：

Steinbrunn, Torsten ^{[1
,2
,3
,4
]}

Shirasaki, Ryosuke ^{[1
,2
,3
,5
]}

Dashevsky, Olga ^{[1
,2
,3
]}

Tang, Huihui ^{[1
,2
,3
]}

Yamano, Shizuka ^{[1
]}

Teoh, Phaik Ju ^{[1
,2
,3
,6
]}

Leypoldt, Lisa ^{[1
,2
,3
,7
]}

Mizuno, Rin ^{[1
,2
,3
]}

Glassner, Brian ^{[1
,2
,3
]}

Simoes, Ricardo de Matos ^{[1
,2
,3
]}

Christensen, James ^{[8
]}

Mitsiades, Constantine ^{[1
,2
,3
,9
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA

[2] Harvard Med Sch, Dept Med, Boston, MA USA

[3] Broad Inst MIT & Harvard, Cambridge, MA USA

[4] Univ Hosp Wurzb, Dept Med 2, Wurzburg, Germany

[5] Teikyo Univ Hosp, Dept Med Oncol, Tokyo, Japan

[6] Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore

[7] Univ Med Ctr Hamburg Eppendorf, Dept Hematol Oncol & Bone Marrow Transplantat, Hamburg, Germany

[8] Mirati Therapeut Inc, San Diego, CA USA

[9] Harvard Med Sch, Ludwig Ctr, Boston, MA USA

来源：

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | 2024年 / 24卷

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

P-248

引用

页码：S180 / S181

页数：2

共 5 条

[1] Mutant-specific pharmacological inhibition of KRAS in multiple myeloma and functional genomics studies to identify mechanisms regulating myeloma cell response vs. resistance to KRAS inhibition
Steinbrunn, Torsten
Shirasaki, Ryosuke
Dashevsky, Olga
Tang, Huihui
Yamano, Shizuka
Teoh, Phaik Ju
Leypoldt, Lisa
Sugihara, Takeru
Mizuno, Rin
Kaji, Mariko
Sorrell, Jeffrey
Glassner, Brian
Simoes, Ricardo de Matos
Christensen, James
Mitsiades, Constantine
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2023, 23 : S244 - S244
[2] Targeting Mutant KRAS with Novel Mutant-Specific Pharmacological Inhibitors: Activity Against Myeloma and Other Lymphoid Malignant Cells and Molecular Mechanisms of Resistance
Steinbrunn, Torsten
Shirasaki, Ryosuke
Dashevsky, Olga
Tang, Huihui
Yamano, Shizuka
Mizuno, Rin
Sugihara, Takeru
Teoh, Phaik Ju
Leypoldt, Lisa B.
Kaji, Mariko
Sorrell, Jeffrey
Glassner, Brian J.
Simoes, Ricardo De Matos
Christensen, James
Mitsiades, Constantine S.
BLOOD, 2023, 142
[3] Identifying Factors in Multiple Myeloma Controlling Response to B-Cell Maturation Antigen (BCMA)-Targeted Immunotherapy Using CRISPR-Based Functional Genomics
Ramkumar, Poornima
Leong, Jaime
Seyler, Meghan
Georgoulis, Stratton J.
Wittsten, Axel Hyrenius
Choudhry, Priya
Roybal, Kole
Wiita, Arun P.
Kampmann, Martin
BLOOD, 2018, 132
[4] CRISPR-Based Genome-Wide Knockout and Overexpression Screens Identify Novel and Putative Acquired Resistance Mechanisms to Pharmacological Inhibition of ALK in Human Neuroblastoma Cell Lines
Lee, L. C.
Han, M.
Luo, J.
Turner, S.
JOURNAL OF MOLECULAR DIAGNOSTICS, 2016, 18 (06): : 1003 - 1003
[5] Integrated Evaluation of Results from Genome-Wide Association Studies and Crispr/Cas9-Based Functional Genomics in Myeloma: Implications for Cell-Autonomous Vs. Non-Autonomous Role of Candidate Genes in Myeloma Pathophysiology
Simoes, Ricardo De Matos
Matthews, Geoffrey M.
Hu, Yiguo
Glassner, Brian
Bariteau, Megan A.
Sheffer, Michal
Shirasaki, Ryosuke
Mitsiades, Constantine S.
BLOOD, 2016, 128 (22)

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