The Role of Wnt5a in Inflammatory Diseases

被引：0

作者：

Yu, Xin-hua ^{[1
]}

Guo, Xin-ning ^{[2
]}

Li, Kui ^{[3
]}

Li, Jia-wei ^{[3
]}

Wang, Kaijin ^{[3
]}

Wang, Dan ^{[4
]}

Liu, Bi-cui ^{[3
]}

机构：

[1] Chongqing Med Univ, Bishan Hosp, Dept Pediat, Chongqing, Peoples R China

[2] Shanghai Jiao Tong Univ, Renji Hosp, Dept Cardiol, Shanghai, Peoples R China

[3] Chongqing Med Univ, Bishan Hosp, Dept Resp & Crit Care Med, Chongqing, Peoples R China

[4] Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing, Peoples R China

来源：

IMMUNOLOGY | 2025年 / 174卷 / 02期

关键词：

immune homeostasis; inflammation; inhibitory/activating receptors; JAKs/STATs; Wnt5a; CELL POLARITY; WINGLESS HOMOLOG; ADIPOSE-TISSUE; TGF-BETA; KAPPA-B; EXPRESSION; PROLIFERATION; WNT-5A; PATHOGENESIS; ATHEROSCLEROSIS;

D O I：

10.1111/imm.13882

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Wnt5a plays an important role in cell development and maturation and is closely associated with various diseases, such as malignant tumours, metabolic disorders, fibrosis, growth and development. Recent studies have shown that Wnt5a expression and signal transduction are strongly involved in the inflammatory response. This study comprehensively reviewed the latest research progress on the association between Wnt5a and several inflammatory diseases, such as sepsis, asthma, chronic obstructive pulmonary disease, tuberculosis, rheumatoid arthritis, atherosclerosis and psoriasis vulgare. We elucidated the mechanism by which the Wnt5a protein is involved in the pathogenesis of these diseases, providing a basis for the prevention and treatment of inflammatory diseases.

引用

页码：203 / 212

页数：10

共 50 条

[1] Role of Wnt5a in the Pathogenesis of Inflammatory Diseases
Pashirzad, Mehran
Shafiee, Mojtaba
Rahmani, Farzad
Behnam-Rassouli, Reihane
Hoseinkhani, Fatemeh
Ryzhikov, Mikhail
Binabaj, Maryam Moradi
Parizadeh, Mohammad Reza
Avan, Amir
Hassanian, Seyed Mahdi
JOURNAL OF CELLULAR PHYSIOLOGY, 2017, 232 (07) : 1611 - 1616
[2] Wnt5a: its signalling, functions and implication in diseases
Kikuchi, A.
Yamamoto, H.
Sato, A.
Matsumoto, S.
ACTA PHYSIOLOGICA, 2012, 204 (01) : 17 - 33
[3] Wnt5a: Its signaling, cellular functions, and diseases
Kikuchi, A.
Yamamoto, H.
Sato, A.
Matsumoto, S.
Hanaki, H.
DIFFERENTIATION, 2010, 80 : S15 - S15
[4] Role of Wnt5a signals in allergic asthma
Singla, A.
Peters, K.
Reuter, S.
Beckert, H.
Busse, S.
Bonowitz, P.
Peters, M.
Taube, C.
EUROPEAN RESPIRATORY JOURNAL, 2022, 60
[5] The role of Wnt5a in prostate gland development
Huang, Liwei
Pu, Yongbing
Hu, Wen Yang
Birch, Lynn
Luccio-Camelo, Douglas
Yamaguchi, Terry
Prins, Gail S.
DEVELOPMENTAL BIOLOGY, 2009, 328 (02) : 188 - 199
[6] Role of wnt5a in Metabolic Inflammation in Humans
Relling, Isabelle
Akcay, Guel
Fangmann, Daniela
Knappe, Carina
Schulte, Dominik Maria
Hartmann, Katharina
Mueller, Nike
Tuerk, Kathrin
Dempfle, Astrid
Franke, Andre
Schreiber, Stefan
Laudes, Matthias
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2018, 103 (11): : 4253 - 4264
[7] The emerging role of Wnt5a in the promotion of a pro-inflammatory and immunosuppressive tumor microenvironment
Pablo Lopez-Bergami
Gastón Barbero
Cancer and Metastasis Reviews, 2020, 39 : 933 - 952
[8] The emerging role of Wnt5a in the promotion of a pro-inflammatory and immunosuppressive tumor microenvironment
Lopez-Bergami, Pablo
Barbero, Gaston
CANCER AND METASTASIS REVIEWS, 2020, 39 (03) : 933 - 952
[9] Wnt5a and preeclampsia: is Wnt5a really a causative factor of preeclampsia?
Takahashi, Hironori
Takizawa, Toshihiro
Matsubara, Shigeki
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2017, 30 (09): : 1087 - 1088
[10] Wnt5a: A player in the pathogenesis of atherosclerosis and other inflammatory disorders
Bhatt, Pooja M.
Malgor, Ramiro
ATHEROSCLEROSIS, 2014, 237 (01) : 155 - 162

← 1 2 3 4 5 →