Potential circadian rhythms impacts on amblyopia treatment outcomes

Traditional treatments for amblyopia, such as patching and atropine penalization, often yield variable outcomes, underscoring the need for alternative or supplementary strategies. Circadian rhythms, which regulate various physiological processes including those associated with ocular health, may significantly influence the success of these treatments. The report proposes three hypotheses: (1) aligning amblyopia treatments with circadian rhythms through the modulation of melatonin and dopamine levels may enhance treatment responsiveness, (2) synchronizing treatment schedules with the patient's diurnal rhythms could improve effectiveness, and (3) disruptions in circadian rhythms might negatively affect treatment outcomes. The expected implications of these hypotheses suggest a need for further research into the interplay between circadian rhythms and amblyopia therapy to optimize outcomes.