Sleep duration, mediating biomarkers, and risk of microvascular complications among individuals with type 2 diabetes: A prospective cohort study

被引：0
作者：
Niu, Xiaoge [1 ,2 ]
Liu, Hongwei [3 ,4 ]
Wang, Yanxi [5 ]
Lu, Yanfang [1 ,2 ]
Jiao, Xiaojing [1 ,2 ]
Ren, Yafeng [1 ,2 ]
Yan, Lei [1 ,2 ]
Zhang, Shaokai [3 ,4 ]
Cao, Huixia [1 ,2 ]
Shao, Fengmin [1 ,2 ]
机构：
[1] Zhengzhou Univ, Henan Prov Clin Res Ctr Kidney Dis, Dept Nephrol, Henan Prov Key Lab Kidney Dis & Immunol,Henan Prov, Zhengzhou 450053, Peoples R China
[2] Zhengzhou Univ, Peoples Hosp, Zhengzhou 450053, Peoples R China
[3] Zhengzhou Univ, Affiliated Canc Hosp, Dept Canc Epidemiol, Zhengzhou 450008, Peoples R China
[4] Henan Canc Hosp, Zhengzhou 450008, Peoples R China
[5] Henan Univ Tradit Chinese Med, Zhengzhou 450046, Peoples R China
来源：
DIABETES RESEARCH AND CLINICAL PRACTICE | 2025年 / 221卷
关键词：
Cohort study; Diabetic microvascular complications; Mediation analysis; Sleep duration; Type; 2; diabetes; LIFE-STYLE; HEALTH; METAANALYSIS; QUALITY; IMPACT;
D O I：
10.1016/j.diabres.2025.112026
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: Associations between sleep duration and incident diabetic microvascular complications remain uncertain. The potential biological pathways underlying the association are unclear. Methods: This prospective cohort study included 24,081 participants with type 2 diabetes from the UK Biobank. Habitual sleep duration was obtained via a baseline questionnaire. Associations of sleep duration with microvascular complications were analyzed using Cox regression models. Results: The association of sleep duration with composite microvascular complications followed U-shaped patterns. Compared with sleeping for 7 hrs/day, the hazard ratios (95 % confidence intervals) of <= 5 and >= 10 hrs/ day were 1.21 (1.09, 1.35) and 1.24 (1.09, 1.42) for the composite outcome, 1.20 (1.04, 1.38) and 1.30 (1.09, 1.54) for diabetic kidney disease, 1.61 (1.30, 2.00) and 1.35 (1.01, 1.79) for diabetic neuropathy, and 1.10 (0.93, 1.30) and 1.17 (0.95, 1.44) for diabetic retinopathy. Body mass index, gamma-glutamyl transferase, C-reactive protein, alkaline phosphatase, total cholesterol, and low-density lipoprotein cholesterol collectively explained 20.34 % of the association between sleep duration and composite microvascular complications. Conclusions: Our study demonstrated that both short and long sleep durations were independently associated with increased risk of diabetic microvascular complications. The associations were partially mediated by metabolic biomarkers related to obesity, systemic inflammation, liver function, and lipid profile.
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