Endometriosis (EMs) is a prevalent chronic gynecological condition that depends on estrogen, marked by the presence of active endometrial tissue (glands and stroma) outside the uterus. Although pathologically benign, it exhibits biological behaviors such as invasion and metastasis akin to malignant tumors. Endometriosis-associated ovarian carcinoma (EAOC), arising from malignant transformation of EMs, poses significant clinical challenges. However, the mechanisms underlying EAOC pathogenesis remain incompletely understood, with a lack of reliable biomarkers for early diagnosis and personalized treatment strategies. Considering the significant number of EMs patients and the extended period during which malignant transformation can occur, EAOC deserves significant attention. Current research both domestically and internationally indicates that the pathogenesis of EAOC is complex, involving genetic mutations, immune microenvironment, oxidative stress, epigenetic changes, and related areas. This review summarizes the mechanisms underlying the development of EAOC.
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Univ Adelaide, Res Ctr Reprod Hlth, Robinson Inst, Adelaide, SA 5005, AustraliaUniv Adelaide, Res Ctr Reprod Hlth, Robinson Inst, Adelaide, SA 5005, Australia
Hull, M. Louise
Nisenblat, Victoria
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机构:Univ Adelaide, Res Ctr Reprod Hlth, Robinson Inst, Adelaide, SA 5005, Australia
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Johns Hopkins Med Inst, Kimmel Canc Ctr, Dept Obstet Gynecol, Baltimore, MD 21205 USAJohns Hopkins Med Inst, Kimmel Canc Ctr, Dept Pathol, Baltimore, MD 21205 USA
Wang, Tian-Li
Glas, Ruth
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Univ Calif Los Angeles, David Geffen Sch Med, Div Hematol Oncol, Los Angeles, CA 90095 USAJohns Hopkins Med Inst, Kimmel Canc Ctr, Dept Pathol, Baltimore, MD 21205 USA
Glas, Ruth
Slamon, Dennis
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Univ Calif Los Angeles, David Geffen Sch Med, Div Hematol Oncol, Los Angeles, CA 90095 USAJohns Hopkins Med Inst, Kimmel Canc Ctr, Dept Pathol, Baltimore, MD 21205 USA
Slamon, Dennis
Velculescu, Victor E.
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Johns Hopkins Med Inst, Kimmel Canc Ctr, Ludwig Ctr, Baltimore, MD 21205 USA
Johns Hopkins Med Inst, Kimmel Canc Ctr, Howard Hughes Med Inst, Baltimore, MD 21205 USAJohns Hopkins Med Inst, Kimmel Canc Ctr, Dept Pathol, Baltimore, MD 21205 USA
Velculescu, Victor E.
Kuman, Robert J.
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Johns Hopkins Med Inst, Kimmel Canc Ctr, Dept Pathol, Baltimore, MD 21205 USA
Johns Hopkins Med Inst, Kimmel Canc Ctr, Dept Obstet Gynecol, Baltimore, MD 21205 USAJohns Hopkins Med Inst, Kimmel Canc Ctr, Dept Pathol, Baltimore, MD 21205 USA
Kuman, Robert J.
Shih, Ie-Ming
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Johns Hopkins Med Inst, Kimmel Canc Ctr, Dept Pathol, Baltimore, MD 21205 USA
Johns Hopkins Med Inst, Kimmel Canc Ctr, Dept Obstet Gynecol, Baltimore, MD 21205 USAJohns Hopkins Med Inst, Kimmel Canc Ctr, Dept Pathol, Baltimore, MD 21205 USA
机构:
Univ Adelaide, Res Ctr Reprod Hlth, Robinson Inst, Adelaide, SA 5005, AustraliaUniv Adelaide, Res Ctr Reprod Hlth, Robinson Inst, Adelaide, SA 5005, Australia
Hull, M. Louise
Nisenblat, Victoria
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h-index: 0
机构:Univ Adelaide, Res Ctr Reprod Hlth, Robinson Inst, Adelaide, SA 5005, Australia
机构:
Johns Hopkins Med Inst, Kimmel Canc Ctr, Dept Obstet Gynecol, Baltimore, MD 21205 USAJohns Hopkins Med Inst, Kimmel Canc Ctr, Dept Pathol, Baltimore, MD 21205 USA
Wang, Tian-Li
Glas, Ruth
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h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Div Hematol Oncol, Los Angeles, CA 90095 USAJohns Hopkins Med Inst, Kimmel Canc Ctr, Dept Pathol, Baltimore, MD 21205 USA
Glas, Ruth
Slamon, Dennis
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h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Div Hematol Oncol, Los Angeles, CA 90095 USAJohns Hopkins Med Inst, Kimmel Canc Ctr, Dept Pathol, Baltimore, MD 21205 USA
Slamon, Dennis
Velculescu, Victor E.
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Med Inst, Kimmel Canc Ctr, Ludwig Ctr, Baltimore, MD 21205 USA
Johns Hopkins Med Inst, Kimmel Canc Ctr, Howard Hughes Med Inst, Baltimore, MD 21205 USAJohns Hopkins Med Inst, Kimmel Canc Ctr, Dept Pathol, Baltimore, MD 21205 USA
Velculescu, Victor E.
Kuman, Robert J.
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Med Inst, Kimmel Canc Ctr, Dept Pathol, Baltimore, MD 21205 USA
Johns Hopkins Med Inst, Kimmel Canc Ctr, Dept Obstet Gynecol, Baltimore, MD 21205 USAJohns Hopkins Med Inst, Kimmel Canc Ctr, Dept Pathol, Baltimore, MD 21205 USA
Kuman, Robert J.
Shih, Ie-Ming
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Med Inst, Kimmel Canc Ctr, Dept Pathol, Baltimore, MD 21205 USA
Johns Hopkins Med Inst, Kimmel Canc Ctr, Dept Obstet Gynecol, Baltimore, MD 21205 USAJohns Hopkins Med Inst, Kimmel Canc Ctr, Dept Pathol, Baltimore, MD 21205 USA