Colorectal cancer: Recent advances in management and treatment

被引：36

作者：

Fadlallah, Hiba ^{[1
]}

El Masri, Jad ^{[1
]}

Fakhereddine, Hiam ^{[1
]}

Youssef, Joe ^{[1
]}

Chemaly, Chrystelle ^{[1
]}

Doughan, Samer ^{[2
]}

Abou-Kheir, Wassim ^{[1
]}

机构：

[1] Amer Univ Beirut, Dept Anat Cell Biol & Physiol Sci, Bliss St, Beirut 11072020, Lebanon

[2] Amer Univ Beirut, Med Ctr, Dept Surg, Beirut 11072020, Lebanon

来源：

WORLD JOURNAL OF CLINICAL ONCOLOGY | 2024年 / 15卷 / 09期

关键词：

Colorectal cancer; Treatment; Surgery; Chemotherapy; Targeted therapy; Immunotherapy; ADVANCED RECTAL-CANCER; III COLON-CANCER; CETUXIMAB PLUS IRINOTECAN; MISMATCH REPAIR-DEFICIENT; ASTRO PRACTICE PARAMETER; PROTON-BEAM THERAPY; RADIATION-THERAPY; OPEN-LABEL; 1ST-LINE TREATMENT; DOUBLE-BLIND;

D O I：

10.5306/wjco.v15.i9.1136

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC) is the third most common cancer worldwide, and the second most common cause of cancer-related death. In 2020, the estimated number of deaths due to CRC was approximately 930000, accounting for 10% of all cancer deaths worldwide. Accordingly, there is a vast amount of ongoing research aiming to find new and improved treatment modalities for CRC that can potentially increase survival and decrease overall morbidity and mortality. Current management strategies for CRC include surgical procedures for resectable cases, and radiotherapy, chemotherapy, and immunotherapy, in addition to their combination, for non-resectable tumors. Despite these options, CRC remains incurable in 50% of cases. Nonetheless, significant improvements in research techniques have allowed for treatment approaches for CRC to be frequently updated, leading to the availability of new drugs and therapeutic strategies. This review summarizes the most recent therapeutic approaches for CRC, with special emphasis on new strategies that are currently being studied and have great potential to improve the prognosis and lifespan of patients with CRC.

引用

页数：22

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