Educational attainment, Aβ, tau, and structural brain reserve in Alzheimer's disease

被引：1
作者：
Cai, Yue [1 ]
Fang, Lili [1 ]
Li, Anqi [1 ,2 ]
Yang, Jie [1 ,3 ]
Zhou, Xin [1 ,4 ]
He, Zhengbo [1 ,5 ]
Sun, Pan [1 ]
Wang, Qingyong [6 ]
Guo, Tengfei [1 ,7 ,8 ]
机构：
[1] Shenzhen Bay Lab, Inst Neurol & Psychiat Disorders, 5 Kelian Rd, Shenzhen 518132, Peoples R China
[2] Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Peoples R China
[3] Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China
[4] Hainan Univ, Sch Biomed Engn, Haikou, Peoples R China
[5] Harbin Inst Technol, Sch Life Sci & Technol, Harbin, Peoples R China
[6] Shenzhen Guangming Dist Peoples Hosp, Dept Neurol, Shenzhen 518107, Peoples R China
[7] Shenzhen Bay Lab, Inst Biomed Engn, Shenzhen, Peoples R China
[8] Peking Univ, Inst Biomed Engn, Shenzhen Grad Sch, Shenzhen, Peoples R China
来源：
ALZHEIMERS & DEMENTIA | 2025年 / 21卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Alzheimer's disease; brain reserve; educational attainment; longitudinal cognitive decline; tau tangles; COGNITIVE DECLINE; AMYLOID DEPOSITION; ASSOCIATION; BURDEN; VOLUME;
D O I：
10.1002/alz.14400
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Introduction: Alzheimer's disease (AD) patients with higher educational attainment (EA) often exhibit better cognitive function. However, the relationship among EA status, AD pathology, structural brain reserve, and cognitive decline requires further investigation. Methods: We compared cognitive performance across different amyloid beta (A beta) positron emission tomography (A +/-) statuses and EA levels (High EA/Low EA). We examined the effects of A beta plaques, tau tangles, and gray matter volume (GMV) on the relationship between EA and domain-specific cognitive decline. Results: A+/High-EA individuals exhibited slower cognitive decline in global cognition and language domains than A+/Low-EA individuals. This cognitive benefit was independently and synergistically explained by reduced AD pathology, including lower A beta and tau burdens, as well as preserved GMV. Additionally, High-EA individuals experienced a median delay of 1.9 years in the onset of significant brain atrophy among A+ individuals. Discussion: These findings highlight the independent and synergistic contributions of EA-associated AD pathology and GMV alterations to longitudinal cognitive decline.
引用
收藏
页数：15
相关论文
共 58 条
[1]   Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly [J].
Aizenstein, Howard Jay ;
Nebes, Robert D. ;
Saxton, Judith A. ;
Price, Julie C. ;
Mathis, Chester A. ;
Tsopelas, Nicholas D. ;
Ziolko, Scott K. ;
James, Jeffrey A. ;
Snitz, Beth E. ;
Houck, Patricia R. ;
Bi, Wenzhu ;
Cohen, Ann D. ;
Lopresti, Brian J. ;
DeKosky, Steven T. ;
Halligan, Edythe M. ;
Klunk, William E. .
ARCHIVES OF NEUROLOGY, 2008, 65 (11) :1509-1517
[2]   Education and cognitive decline in older Americans - Results from the AHEAD sample [J].
Alley, Dawn ;
Suthers, Kristen ;
Crimmins, Eileen .
RESEARCH ON AGING, 2007, 29 (01) :73-94
[3]   Compensatory mechanisms in higher-educated subjects with Alzheimer's disease: a study of 20 years of cognitive decline [J].
Amieva, Helene ;
Mokri, Hind ;
Le Goff, Melanie ;
Meillon, Celine ;
Jacqmin-Gadda, Helene ;
Foubert-Samier, Alexandra ;
Orgogozo, Jean-Marc ;
Stern, Yaakov ;
Dartigues, Jean-Francois .
BRAIN, 2014, 137 :1167-1175
[4]   The effect of education and occupational complexity on rate of cognitive decline in Alzheimer's patients [J].
Andel, R ;
Vigen, C ;
Mack, WJ ;
Clark, LJ ;
Gatz, M .
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 2006, 12 (01) :147-152
[5]   Resistance vs resilience to Alzheimer disease Clarifying terminology for preclinical studies [J].
Arenaza-Urquijo, Eider M. ;
Vemuri, Prashanthi .
NEUROLOGY, 2018, 90 (15) :695-703
[6]   Relationships between years of education and gray matter volume, metabolism and functional connectivity in healthy elders [J].
Arenaza-Urquijo, Eider M. ;
Landeau, Brigitte ;
La Joie, Renaud ;
Mevel, Katell ;
Mezenge, Florence ;
Perrotin, Audrey ;
Desgranges, Beatrice ;
Bartres-Faz, David ;
Eustache, Francis ;
Chetelat, Gael .
NEUROIMAGE, 2013, 83 :450-457
[7]   Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer's Disease [J].
Binette, Alexa Pichet ;
Vachon-Presseau, Etienne ;
Morris, John ;
Bateman, Randall ;
Benzinger, Tammie ;
Collins, D. Louis ;
Poirier, Judes ;
Breitner, John C. S. ;
Villeneuve, Sylvia .
BIOLOGICAL PSYCHIATRY, 2021, 89 (08) :776-785
[8]   White matter hyperintensities and cognition: Testing the reserve hypothesis [J].
Brickman, Adam M. ;
Siedlecki, Karen L. ;
Muraskin, Jordan ;
Manly, Jennifer J. ;
Luchsinger, Jose A. ;
Yeung, Lok-Kin ;
Brown, Truman R. ;
DeCarli, Charles ;
Stern, Yaakov .
NEUROBIOLOGY OF AGING, 2011, 32 (09) :1588-1598
[9]   Association of β-Amyloid, Microglial Activation, Cortical Thickness, and Metabolism in Older Adults Without Dementia [J].
Cai, Yue ;
Shi, Dai ;
Lan, Guoyu ;
Chen, Linting ;
Jiang, Yanni ;
Zhou, Liemin ;
Guo, Tengfei .
NEUROLOGY, 2024, 102 (07)
[10]   Initial levels of β-amyloid and tau deposition have distinct effects on longitudinal tau accumulation in Alzheimer's disease [J].
Cai, Yue ;
Du, Jing ;
Li, Anqi ;
Zhu, Yalin ;
Xu, Linsen ;
Sun, Kun ;
Ma, Shaohua ;
Guo, Tengfei .
ALZHEIMERS RESEARCH & THERAPY, 2023, 15 (01)
123456