A Comparison of Stereotactic Radiation Therapy in Elderly Patients with Central or Peripheral Stage I-II (T1-3 N0 M0) Non-Small Cell Lung Cancer

被引：0

作者：

Ji, Xiaoqin ^{[1
]}

Shi, Xuebing ^{[2
]}

Hu, Jun ^{[3
]}

Jiang, Wanrong ^{[3
]}

Zhou, Bin ^{[3
]}

Zhou, Houlong ^{[3
]}

Yuan, Xi ^{[3
]}

Li, Yikun ^{[3
]}

Huang, Hua ^{[3
]}

Wang, Jiasheng ^{[3
]}

Ding, Wei ^{[3
]}

Wang, Yong ^{[4
]}

Sun, Xiangdong ^{[3
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Radiat Oncol, Nanjing, Peoples R China

[2] Nanjing Jiangbei Hosp, Dept Radiat Oncol, Nanjing, Peoples R China

[3] Nanjing Univ, Jinling Hosp, Affiliated Hosp, Med Sch,Dept Radiat Oncol, Nanjing, Peoples R China

[4] Nanjing Univ, Jinling Hosp, Affiliated Hosp, Med Sch,Dept Outpatient Clin, Nanjing, Peoples R China

来源：

CANCER MANAGEMENT AND RESEARCH | 2024年 / 16卷

关键词：

Non-small cell lung cancer; stereotactic body radiation therapy; central lung cancer; elderly patients; propensity score matching; LOCATED EARLY-STAGE; ABLATIVE RADIOTHERAPY; BODY RADIOTHERAPY; OUTCOMES; TUMORS; SURVIVAL; TOXICITY; ONCOLOGY; SBRT;

D O I：

10.2147/CMAR.S483569

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: The objective of this study was to compare the clinical outcomes of stereotactic body radiation therapy (SBRT) in elderly patients aged 65 or older with clinical stage I-II non-small-cell lung cancer (NSCLC), specifically examining the differences between centrally located lung tumors and peripherally located lung tumors. Methods: From April 2009 to January 2020, a total of 136 patients with 136 tumors (65 central, 71 peripheral; NSCLC) at an early stage (T1-3N0M0) were treated with SBRT at a single institution. Central/peripheral location was assessed retrospectively on planning CT scans. A propensity score matching analysis was utilized to compare the two groups. In addition, the prognosis and related toxicity were compared between the two study arms. Results: A total of 33 central tumors and 33 peripheral tumors were matched and analyzed. The results showed no significant differences in overall survival (OS) and progression-free survival (PFS) between the two groups. The 2-year OS was 71.88% (95% CI, 57.87%-89.27%) in the central lung cancer group, while it was 93.94% (95% CI, 86.14%-100.00%) in the peripheral lung cancer group (P=0.462). The 2-year PFS was 43.75% in the central lung cancer group, while it was 78.79% in the peripheral lung cancer group (P=0.279). Further subgroup analysis indicated that the location of peripheral tumor have a positive impact on OS in patients with adenocarcinoma. The occurrence of local failure, regional failure, or distant failure was comparable between central and peripheral tumors. There was no statistically significant difference in toxicity between the central and the peripheral tumor groups. Conclusion: The outcomes of SBRT for central tumors versus peripheral lung tumors in elderly patients with early-stage NSCLC were similar. SBRT demonstrated a similar level of safety in terms of toxicity for both central and peripheral lung tumors.

引用

页码：1557 / 1570

页数：14

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