Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos: A 10-year retrospective review

被引：1

作者：

Rao, Hridya ^{[1
]}

Weiss, Margaret C. ^{[2
]}

Moon, Jee Young ^{[3
]}

Perreira, Krista M. ^{[4
]}

Daviglus, Martha L. ^{[5
]}

Kaplan, Robert ^{[3
,6
]}

North, Kari E. ^{[7
]}

Argos, Maria ^{[2
,8
]}

Fernandez-Rhodes, Lindsay ^{[1
]}

Sofer, Tamar ^{[9
,10
,11
]}

机构：

[1] Penn State Univ, Dept Biobehav Hlth, University Pk, PA USA

[2] Univ Illinois, Sch Publ Hlth, Dept Epidemiol & Biostat, Chicago, IL USA

[3] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY USA

[4] Univ North Carolina, Sch Med, Sch Med, Chapel Hill, NC USA

[5] Univ Illinois, Inst Minor Hlth Res, Chicago, IL USA

[6] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA USA

[7] Univ North Carolina, Dept Epidemiol, Chapel Hill, NC USA

[8] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA

[9] Harvard Med Sch, Cardiovasc Inst, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[10] Harvard TH Chan Sch Publ Hlth, Biostat, Boston, MA 02115 USA

[11] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

来源：

HUMAN GENETICS AND GENOMICS ADVANCES | 2025年 / 6卷 / 01期

关键词：

GENOME-WIDE ASSOCIATION; POLYGENIC RISK; POPULATION STRATIFICATION; EPIDEMIOLOGY PAGE; LOCI; TRAITS; INDIVIDUALS; DISEASE; HISPANICS/LATINOS; DIVERSITY;

D O I：

10.1016/j.xhgg.2024.100376

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, longitudinal cohort study designed to evaluate environmental, lifestyle, and genetic risk factors as they relate to cardiometabolic and other chronic diseases among Hispanic/Latino populations in the United States. Since the study's inception in 2008, as a result of the study's robust genetic measures, HCHS/SOL has facilitated major contributions to the field of genetic research. This 10-year retrospective review highlights the major findings for genotype-phenotype relationships and advancements in statistical methods owing to the HCHS/SOL. Furthermore, we discuss the ethical and societal challenges of genetic research, especially among Hispanic/Latino adults in the United States. Continued genetic research, ancillary study expansion, and consortia collaboration through HCHS/SOL will further drive knowledge and advancements in human genetics research.

引用

页数：33

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