Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos: A 10-year retrospective review

被引：0
作者：
Rao, Hridya [1 ]
Weiss, Margaret C. [2 ]
Moon, Jee Young [3 ]
Perreira, Krista M. [4 ]
Daviglus, Martha L. [5 ]
Kaplan, Robert [3 ,6 ]
North, Kari E. [7 ]
Argos, Maria [2 ,8 ]
Fernandez-Rhodes, Lindsay [1 ]
Sofer, Tamar [9 ,10 ,11 ]
机构：
[1] Penn State Univ, Dept Biobehav Hlth, University Pk, PA USA
[2] Univ Illinois, Sch Publ Hlth, Dept Epidemiol & Biostat, Chicago, IL USA
[3] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY USA
[4] Univ N Carolina, Sch Med, Sch Med, Chapel Hill, NC USA
[5] Univ Illinois, Inst Minor Hlth Res, Chicago, IL USA
[6] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA USA
[7] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA
[8] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA
[9] Harvard Med Sch, Cardiovasc Inst, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA
[10] Harvard TH Chan Sch Publ Hlth, Biostat, Boston, MA 02115 USA
[11] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA
来源：
HUMAN GENETICS AND GENOMICS ADVANCES | 2025年 / 6卷 / 01期
关键词：
GENOME-WIDE ASSOCIATION; POLYGENIC RISK; POPULATION STRATIFICATION; EPIDEMIOLOGY PAGE; LOCI; TRAITS; INDIVIDUALS; DISEASE; HISPANICS/LATINOS; DIVERSITY;
D O I：
10.1016/j.xhgg.2024.100376
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, longitudinal cohort study designed to evaluate environmental, lifestyle, and genetic risk factors as they relate to cardiometabolic and other chronic diseases among Hispanic/Latino populations in the United States. Since the study's inception in 2008, as a result of the study's robust genetic measures, HCHS/SOL has facilitated major contributions to the field of genetic research. This 10-year retrospective review highlights the major findings for genotype-phenotype relationships and advancements in statistical methods owing to the HCHS/SOL. Furthermore, we discuss the ethical and societal challenges of genetic research, especially among Hispanic/Latino adults in the United States. Continued genetic research, ancillary study expansion, and consortia collaboration through HCHS/SOL will further drive knowledge and advancements in human genetics research.
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页数：33
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