COVID-19 Vaccination and Transient Increase in CD4/CD8 Cell Counts in People with HIV: Evidence from China

被引：0
|
作者：
Li, Yanyan [1 ,2 ]
Lin, Yingying [3 ]
Yi, Yunyun [4 ]
Zhu, Na [1 ,2 ]
Cui, Xinyu [1 ,2 ]
Li, Xin [1 ,2 ,3 ]
机构：
[1] Capital Med Univ, Beijing Ditan Hosp, Ctr Integrat Med, Beijing 100015, Peoples R China
[2] Capital Med Univ, Beijing Ditan Hosp, Natl Ctr Infect Dis, Beijing 100015, Peoples R China
[3] Peking Univ, Ditan Teaching Hosp, Ctr Integrat Med, Beijing 100015, Peoples R China
[4] Peoples Liberat Army Gen Hosp, Med Ctr 8, TB Prevent & Control Key Lab, Senior Dept TB,Beijing Key Lab New Tech TB Diag &, Beijing 100853, Peoples R China
来源：
VACCINES | 2024年 / 12卷 / 12期
关键词：
HIV; COVID-19; vaccine; CD4; count; CD4/CD8; ratio; immune response; IMMUNOGENICITY; SARS-COV-2; SAFETY; RNA;
D O I：
10.3390/vaccines12121365
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Objectives: Accumulating evidence has confirmed the efficacy and safety of COVID-19 vaccines against SARS-CoV-2 infection. However, the effect of COVID-19 vaccination on immuno-virological parameters in people with HIV (PWH) is uncertain. Methods: A total of 372 PWH treated at Beijing Ditan Hospital were included. Unvaccinated PWH were matched 1:3 with vaccinated PWH using a propensity score matching algorithm. Differences in immuno-virological markers between the matched groups were analyzed. The Wilcoxon signed rank test was used to test for changes in CD4 and CD8 counts and HIV viral load over two months around vaccination. In addition, we investigated the long-term changes in HIV-related markers in different vaccination dose groups and in the entire vaccinated population. Results: Vaccinated PWH had a higher CD4/CD8 ratio (0.64 (0.49, 0.78) vs. 0.80 (0.56, 1.03), p = 0.037) than unvaccinated PWH within a two-month window after the third dose. There were 337 PWH who received COVID-19 vaccination, and 73.9% (n = 249) received three doses of vaccine. We observed a transient increase in CD4 count and CD4/CD8 ratio within a two-month window after vaccination, especially after the second dose (CD4 count: 583.5 (428.5, 706.8) vs. 618.0 (452.0, 744.0), p = 0.018; CD4/CD8 ratio: 0.70 (0.50, 0.91) vs. 0.71 (0.53, 0.96), p < 0.001)) and the third dose (CD4 count: 575.5 (435.5, 717.0) vs. 577.5 (440.8, 754.8), p = 0.001; CD4/CD8 ratio: 0.70 (0.52, 0.93) vs. 0.79 (0.53, 1.00), p < 0.001)). Recent CD4 counts and CD4/CD8 ratios were lower than after COVID-19 but remained higher than before COVID-19 in vaccinated PWH. In addition, COVID-19 vaccination had no negative effect on HIV viral load. Conclusions: A transient increase in CD4 count and CD4/CD8 ratio was observed after COVID-19 vaccination. However, the enhanced cellular immune response induced by vaccination may diminish over time and return to normal levels. There is no adverse effect of vaccination on HIV viral load.
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页数：14
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