Serum TARC Level as a Predictive Marker of Severe Disease in COVID-19 During the Omicron Variant Period of the Pandemic

被引:0
|
作者
Isono, Taisuke [1 ]
Kojima, Ayaka [1 ]
Nishida, Takashi [1 ]
Kobayashi, Yoichi [1 ]
Ishiguro, Takashi [1 ]
Takaku, Yotaro [1 ]
Kagiyama, Naho [1 ]
Kurashima, Kazuyoshi [1 ]
机构
[1] Saitama Cardiovasc & Resp Ctr, Dept Resp Med, Saitama, Japan
关键词
Key words: COVID-19; TARC; predictive factor; severe disease; vaccine; Omicron variant; TYPE-2; INFLAMMATION; CHEMOKINE; HOSPITALIZATION; THYMUS; RISK;
D O I
10.2169/internalmedicine.4276-24
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives Thymus and activation-regulated chemokine (TARC) can predict severe disease in patients with coronavirus disease 2019 (COVID-19). However, no reports have addressed the predictive value of TARC with the widespread use of vaccines and medications for COVID-19 during the Omicron variant period of the pandemic. Methods This single-center prospective cohort study enrolled COVID-19 patients admitted to our institution between December 1, 2021, and August 15, 2022. Patients with respiratory failure due to diseases other than COVID-19 were also excluded. We measured the serum TARC levels of patients at admission. Results We enrolled 157 patients, with 89 in the severe group and 68 in the non-severe group. The severe group was more likely than the non-severe group to include older patients, those with no or one dose of vaccine, and those with interstitial lung disease (ILD). The cutoff level of TARC derived from a receiver operator characteristic curve analysis to predict severe disease was 174.0 pg/mL. The sensitivity, specificity, positive predictive value, and negative predictive value were 72.1%, 69.7%, 64.5%, and 76.5%, respectively. The area under the curve was 0.722 (95% confidence interval: 0.635-0.809). A multivariate analysis showed that 2 vaccination doses were associated with non-severe disease, and TARC <_174 pg/mL was associated with severe disease. Conclusion TARC was a predictive factor for severe disease, but its cutoff value was higher and its predictive accuracy lower than those in previous reports. We surmised that during the Omicron variant period of the pandemic, the widespread use of vaccines and medications for COVID-19 decreased the predictive accuracy of TARC.
引用
收藏
页数:8
相关论文
共 50 条
  • [21] COVID-19 Outcomes in Kidney Transplant During in the Period of Omicron Predominance
    Bernardo, Joao F.
    Goncalves, Sara
    Rodrigues, Natacha
    Santos, Noelia L.
    Goncalves, Joao A.
    Abreu, Fernando
    Neves, Marta R.
    Santana, Alice
    Lopes, Jose A.
    Godinho, Iolanda
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2022, 33 (11): : 319 - 319
  • [22] REAL-WORLD EXPERIENCE WITH COVID-19 THERAPY IN KIDNEY TRANSPLANT PATIENTS DURING THE OMICRON VARIANT PERIOD
    Villanego Fernandez, Florentino
    Alonso, Marta
    Vigara Sanchez, Luis Alberto
    Rodriguez Mateos, Maria Eugenia
    Eady Alonso, Myriam
    Garcia-Doncel, Ana Garcia
    Minguez Mananes, Maria del Carmen
    Montero Escobar, Maria Elisa
    Segurado Toston, Oscar
    Garcia, Teresa
    Mazuecos, Auxiliadora
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2023, 38 : I945 - I945
  • [23] Platelet aggregates, a marker of severe COVID-19 disease
    Rampotas, Alexandros
    Pavord, Sue
    JOURNAL OF CLINICAL PATHOLOGY, 2021, 74 (11) : 750 - 751
  • [24] Evaluation of the Anxiety Level of Mothers of Children with Epilepsy during the COVID-19 Pandemic Period
    Celik, Halil
    Acikel, Sadettin Burak
    Ozdemir, Fatih Mehmet Akif
    Aksoy, Erhan
    Oztoprak, Ulkuhan
    Cucu, Ergin
    Kucur, Ozge
    Ceylan, Nesrin
    Yuksel, Deniz
    EUROPEAN NEUROLOGY, 2021, 84 (03) : 192 - 199
  • [25] Omicron SARS-CoV-2 variant: a new chapter in the COVID-19 pandemic
    Karim, Salim S. Abdool
    Karim, Quarraisha Abdool
    LANCET, 2021, 398 (10317): : 2126 - +
  • [26] Combination of serum lactate dehydrogenase and sex is predictive of severe disease in patients with COVID-19
    Hu, Jin
    Zhou, Jun
    Dong, Fang
    Tan, Jie
    Wang, Shuntao
    Li, Zhi
    Zhang, Ximeng
    Zhang, Huiqiong
    Ming, Jie
    Huang, Tao
    MEDICINE, 2020, 99 (42) : E22774
  • [27] Nirmatrelvir Use and Severe Covid-19 Outcomes during the Omicron Surge
    Arbel, Ronen
    Sagy, Yael Wolff
    Hoshen, Moshe
    Battat, Erez
    Lavie, Gil
    Sergienko, Ruslan
    Friger, Michael
    Waxman, Jacob G.
    Dagan, Noa
    Balicer, Ran
    Ben-Shlomo, Yatir
    Peretz, Alon
    Yaron, Shlomit
    Serby, Danielle
    Hammerman, Ariel
    Netzer, Doron
    NEW ENGLAND JOURNAL OF MEDICINE, 2022, 387 (09): : 790 - 798
  • [28] COVID-19 disease severity in persons infected with the Omicron variant compared with the Delta variant in Qatar
    Butt, Adeel A.
    Dargham, Soha R.
    Tang, Patrick
    Chemaitelly, Hiam
    Hasan, Mohammad R.
    Coyle, Peter V.
    Kaleeckal, Anvar H.
    Latif, Ali Nizar
    Loka, Srusvin
    Shaik, Riyazuddin M.
    Zaqout, Ahmed
    Almaslamani, Muna A.
    Al Khal, Abdullatif
    Bertollini, Roberto
    Abou-Samra, Abdul-Badi
    Abu-Raddad, Laith J.
    JOURNAL OF GLOBAL HEALTH, 2022, 12
  • [29] COVID-19 disease severity in US Veterans infected during Omicron and Delta variant predominant periods
    Mayr, Florian B.
    Talisa, Victor B.
    Castro, Alexander D.
    Shaikh, Obaid S.
    Omer, Saad B.
    Butt, Adeel A.
    NATURE COMMUNICATIONS, 2022, 13 (01)
  • [30] COVID-19 disease severity in US Veterans infected during Omicron and Delta variant predominant periods
    Florian B. Mayr
    Victor B. Talisa
    Alexander D. Castro
    Obaid S. Shaikh
    Saad B. Omer
    Adeel A. Butt
    Nature Communications, 13