Advances in preclinical and clinical studies of oncolytic virus combination therapy

被引:0
|
作者
Du, Wenlong [1 ]
Na, Jintong [1 ]
Zhong, Liping [1 ,2 ]
Zhang, Pumin [1 ]
机构
[1] Guangxi Med Univ, Natl Ctr Int Res Biotargeting Theranost, Collaborat Innovat Ctr Targeting Tumor Diag & Ther, State Key Lab Targeting Oncol,Guangxi Key Lab Biot, Nanning, Peoples R China
[2] Guangxi Med Univ, Pharmaceut Coll, Nanning, Guangxi, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2025年 / 15卷
关键词
oncolytic virus; tumor therapy; combined treatment; clinical trials; immunity; T-CELL THERAPY; NEWCASTLE-DISEASE VIRUS; PHASE-II; IMMUNOTHERAPY; CHEMOTHERAPY; VIROTHERAPY; ADENOVIRUS; TRIAL; INJECTION; ELICITS;
D O I
10.3389/fonc.2025.1545542
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Oncolytic viruses represent a distinct class of viruses that selectively infect and destroy tumor cells while sparing normal cells. Despite their potential, oncolytic viruses encounter several challenges as standalone therapies. Consequently, the combination of oncolytic viruses with other therapeutic modalities has emerged as a prominent research focus. This paper summarizes the tumor-killing mechanisms of oncolytic viruses, explores their integration with radiotherapy, chemotherapy, immune checkpoint inhibitors, CAR-T, and CAR-NK therapies, and provides an overview of related clinical trials. By synthesizing these advancements, this study seeks to offer valuable insights for the clinical translation of oncolytic virus combination therapies.
引用
收藏
页数:14
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