Treatment patterns for advanced therapies in Canadians with moderate-to-severe inflammatory bowel disease: a retrospective cohort analysis

Inflammatory bowel disease (IBD) is made up of ulcerative colitis (UC) and Crohn's disease (CD). However, modern medicines for IBD are not always effective. For some patients, the medicine doesn't work, or it stops working after a while. Other patients have to stop taking their medicine because of side effects. Patients like these usually have to change the dose or switch to another medicine.The RECORDED study looked at Canadian patients who had to change their IBD medicine. The researchers were interested in finding out how long they received their first medicine before changing to a different one.The study looked at 330 patients with CD and 344 patients with UC across Canada. Patients with CD switched to a different medicine on average after 12 months. Patients with UC switched to a different medicine on average after 9 months. In most cases, the medicine was stopped because it didn't work or because it caused side effects. The dose of the first medicine was changed in 191 CD patients and 202 UC patients before it was stopped.The RECORDED study shows what treatment patterns look like for Canadians with IBD who had to change their medicine at least once.