Hydrogen Sulfide: A Versatile Molecule and Therapeutic Target in Health and Diseases

被引：2
作者：
Shahid, Aqsa [1 ]
Bhatia, Madhav [1 ]
机构：
[1] Univ Otago, Dept Pathol & Biomed Sci, Christchurch 8140, New Zealand
来源：
BIOMOLECULES | 2024年 / 14卷 / 09期
关键词：
hydrogen sulfide; H2S donors; H2S inhibitors; inflammatory conditions; cardiovascular diseases; viral infections; neurological disorders; therapeutic applications; molecular pathways; ISCHEMIA-REPERFUSION INJURY; PUNCTURE-INDUCED SEPSIS; INDUCED HINDPAW EDEMA; INDUCED HEART-FAILURE; ISOLATED RAT HEARTS; ACUTE-PANCREATITIS; ALZHEIMERS-DISEASE; SUBSTANCE-P; CECAL LIGATION; MOUSE MODEL;
D O I：
10.3390/biom14091145
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In recent years, research has unveiled the significant role of hydrogen sulfide (H2S) in many physiological and pathological processes. The role of endogenous H2S, H2S donors, and inhibitors has been the subject of studies that have aimed to investigate this intriguing molecule. The mechanisms by which H2S contributes to different diseases, including inflammatory conditions, cardiovascular disease, viral infections, and neurological disorders, are complex. Despite noteworthy progress, several questions remain unanswered. H2S donors and inhibitors have shown significant therapeutic potential for various diseases. This review summarizes our current understanding of H2S-based therapeutics in inflammatory conditions, cardiovascular diseases, viral infections, and neurological disorders.
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页数：27
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