Palladium-catalyzed multicomponent [4+2] cycloaddition of 1,4-enynes with CO and arylamines to access polycyclic γ-lactams via dearomative rearrangement

被引：0

作者：

Xue, Qi ^{[1
]}

Fu, Zheng-Li ^{[2
]}

Zhang, Wen-Yu ^{[2
]}

Cheng, Xia-Lu ^{[2
]}

Li, Yang ^{[1
,2
]}

Cai, Hu ^{[1
]}

Li, Jin-Heng ^{[1
,2
,3
,4
]}

机构：

[1] Nanchang Univ, Sch Chem & Chem Engn, Nanchang 330031, Peoples R China

[2] Qingdao Univ Sci & Technol, Coll Chem Engn, Qingdao 266042, Peoples R China

[3] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[4] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 475004, Henan, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2025年 / 12卷 / 06期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1039/d4qo02304h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein we report a palladium-catalyzed intermolecular dearomative [4 + 2] cycloaddition of 1,4-enynes with CO and arylamines. Compared with the well-known Himbert intramolecular arene/allene cycloaddition, this method provides a facile platform for the synthesis of polycyclic gamma-lactams, through the formation of four new chemical bonds (three C-C bonds and one C-N bond) in a single step, with excellent functional-group tolerance and high atom-economy.

引用

页码：1827 / 1832

页数：6