Palladium-catalyzed multicomponent [4+2] cycloaddition of 1,4-enynes with CO and arylamines to access polycyclic γ-lactams via dearomative rearrangement

被引：0
|
作者：
Xue, Qi [1 ]
Fu, Zheng-Li [2 ]
Zhang, Wen-Yu [2 ]
Cheng, Xia-Lu [2 ]
Li, Yang [1 ,2 ]
Cai, Hu [1 ]
Li, Jin-Heng [1 ,2 ,3 ,4 ]
机构：
[1] Nanchang Univ, Sch Chem & Chem Engn, Nanchang 330031, Peoples R China
[2] Qingdao Univ Sci & Technol, Coll Chem Engn, Qingdao 266042, Peoples R China
[3] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
[4] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 475004, Henan, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2025年 / 12卷 / 06期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1039/d4qo02304h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein we report a palladium-catalyzed intermolecular dearomative [4 + 2] cycloaddition of 1,4-enynes with CO and arylamines. Compared with the well-known Himbert intramolecular arene/allene cycloaddition, this method provides a facile platform for the synthesis of polycyclic gamma-lactams, through the formation of four new chemical bonds (three C-C bonds and one C-N bond) in a single step, with excellent functional-group tolerance and high atom-economy.
引用
收藏
页码：1827 / 1832
页数：6
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