Single-step genome-wide association study reveals candidate genes for body mass index trait in Yunong-black pigs

被引:0
作者
Wu, Ziyi [1 ,2 ]
Dou, Tengfei [1 ,2 ]
Wu, Jiahao [1 ]
Bai, Liyao [1 ]
Zhang, Yongqian [2 ,3 ]
Zan, Shengyuan [2 ,3 ]
Yang, Songbai [2 ,3 ]
Zhou, Hao [1 ]
Han, Jinyi [1 ,4 ]
Han, Xuelei [1 ]
Qiao, Ruimin [1 ]
Wang, Kejun [1 ]
Yang, Feng [1 ]
Li, Xin-Jian [1 ,4 ]
Li, Xiu-Ling [1 ,2 ]
机构
[1] Henan Agr Univ, Coll Anim Sci & Technol, Zhengzhou, Henan, Peoples R China
[2] Hebi Inst Engn & Technol, Hebi, Henan, Peoples R China
[3] Henan Yifa Anim Husb Co Ltd, Hebi, Henan, Peoples R China
[4] Sanya Inst, Hainan Acad Agr Sci, Sanya, Peoples R China
关键词
body mass index; de-regressed estimated breeding values; pig; productive traits; single-step genome wide association study; CONFORMATION TRAITS; FULL PEDIGREE;
D O I
10.1111/age.13501
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Body mass index (BMI) can serve as a reasonable indicator of overall body fat content in pigs. This study aimed to identify underlying variants and candidate genes associated with BMI in Yunong-black pigs. A single-step genome-wide association analysis (GWAS) was performed on 1405 BMI records and 924 Yunong-black pigs genotyped using a 50 K SNP Chip. De-regressed estimated breeding values were taken as the response variable in the GWAS. The estimated heritability for BMI was 0.157. Nine significant regions were associated with BMI, accounting for 12.828% of genetic variance, with the highest region explaining 1.969% of the genetic variance. Linkage disequilibrium analysis of the nine significant regions revealed that SNPs in six single-step GWAS-identified genomic regions were all located in the linkage disequilibrium blocks. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses of the 29 protein-coding genes annotated to these regions revealed that FABP2, a key gene associated with BMI in human, was enriched in the fatty acid binding term and the fat digestion and absorption pathway. This study provides a better insight into the genetic architecture of the BMI trait, and offers potential molecular markers for the breeding of Yunong-black pigs.
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页数:6
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