Serum microRNAs as Diagnostic Markers in Polycystic Ovary Syndrome: A Narrative Review

被引:0
|
作者
Lavanya, K. [1 ]
Palaniappan, N. [2 ]
Vinodhini, V. M. [3 ]
Silambanan, Santhi [1 ]
机构
[1] Sri Ramachandra Inst Higher Educ & Res, Dept Biochem, Chennai 600116, Tamil Nadu, India
[2] Sri Ramachandra Inst Higher Educ & Res, Dept Obstet & Gynaecol, Chennai, Tamil Nadu, India
[3] SRM Med Coll Hosp & Res Ctr, Dept Biochem, Chennai, Tamil Nadu, India
关键词
Anovulation; Apoptosis; Biomarkers; Hormones; Hyperandrogenism; CIRCULATING MICRORNAS; CELL-PROLIFERATION; GENE-EXPRESSION; IDENTIFICATION; WOMEN; BIOMARKERS; RECEPTOR; PROFILE; PCOS;
D O I
10.7860/JCDR/2025/74412.20507
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Polycystic Ovarian Syndrome (PCOS) is thought to be common worldwide among middle-aged women. Increased androgen production, recurrent anovulatory cycles and ovaries with multiple cysts are symptoms of this multiorgan endocrine condition. MicroRNAs (miRs) and several candidate genes, including CYP11A, CYP21 and CYP17, have been linked to PCOS. Singlestranded non coding RNAs known as microRNAs have been shown to alter several cell cycle processes, including metabolism, apoptosis, differentiation and proliferation. By targeting hormone receptors and their release, microRNAs influence the production of steroid hormones and play a significant role in the formation and regulation of follicular growth in the ovaries. Physiological development, including physical growth and embryonic development of the ovaries, alter the levels of microRNA expression. It has been discovered that the altered pattern of microRNAs under pathological circumstances is specific to certain disorders. Therefore, a variety of medications that are either agonists or antagonists of microRNAs may be useful in initiating tailored treatments. The profiles of microRNAs differ depending on the tissue from which they originate. Due to ribozyme activity, microRNAs are persistent and resistant to hydrolysis. Since serum microRNAs are present in various bodily fluids, they are novel markers for diseases like PCOS. The microRNA profile constantly changes depending on the pathogenic stage of the disease. There are correlations between the levels of established biomarkers and the up- and down-regulation of certain microRNAs. Furthermore, it has been found that microRNAs are more specific and sensitive than conventional biomarkers. This article was created to address the altered microRNA profiles in systemic circulation and in different ovarian tissues.
引用
收藏
页码:BE1 / BE6
页数:6
相关论文
共 50 条
  • [31] Hyperandrogenism and Metabolic Syndrome Are Associated With Changes in Serum-Derived microRNAs in Women With Polycystic Ovary Syndrome
    Sorensen, Anja E.
    Udesen, Pernille B.
    Maciag, Grzegorz
    Geiger, Julian
    Saliani, Negar
    Januszewski, Andrzej S.
    Jiang, Guozhi
    Ma, Ronald C.
    Hardikar, Anandwardhan A.
    Wissing, Marie Louise M.
    Englund, Anne Lis M.
    Dalgaard, Louise T.
    FRONTIERS IN MEDICINE, 2019, 6
  • [32] MicroRNAs related to androgen metabolism and polycystic ovary syndrome
    Sorensen, Anja E.
    Udesen, Pernille B.
    Wissing, Marie Louise
    Englund, Anne Lis M.
    Dalgaard, Louise T.
    CHEMICO-BIOLOGICAL INTERACTIONS, 2016, 259 : 8 - 16
  • [33] The diagnostic experience of polycystic ovary syndrome: A scoping review of patient perspectives
    Presswala, Batul
    De Souza, Leanne R.
    PATIENT EDUCATION AND COUNSELING, 2023, 113
  • [34] Diagnostic performance of serum total testosterone for Japanese patients with polycystic ovary syndrome
    Iwasa, Takeshi
    Matsuzaki, Toshiya
    Minakuchi, Masahiro
    Tanaka, Naoko
    Shimizu, Fumi
    Hirata, Yohko
    Kuwahara, Akira
    Yasui, Toshiyuki
    Maegawa, Masahiko
    Irahara, Minoru
    ENDOCRINE JOURNAL, 2007, 54 (02) : 233 - 238
  • [35] Bridging the Information Gap in Polycystic Ovary Syndrome: A Narrative Review with Systematic Approach
    Tay, Chau Thien
    Williams, Fleur
    Mousa, Aya
    Teede, Helena
    Burgert, Tania S.
    SEMINARS IN REPRODUCTIVE MEDICINE, 2023, 41 (01/02) : 12 - 19
  • [36] Nutrition Strategy and Life Style in Polycystic Ovary Syndrome-Narrative Review
    Szczuko, Malgorzata
    Kikut, Justyna
    Szczuko, Urszula
    Szydlowska, Iwona
    Nawrocka-Rutkowska, Jolanta
    Zietek, Maciej
    Verbanac, Donatella
    Saso, Luciano
    NUTRIENTS, 2021, 13 (07)
  • [37] Serum diagnostic markers for malignant pleural mesothelioma: a narrative review
    Wang, Jing-Jing
    Yan, Li
    TRANSLATIONAL CANCER RESEARCH, 2022, 11 (12) : 4434 - 4440
  • [38] The importance of inflammation markers in polycystic ovary syndrome
    Ozay, Ali Cenk
    Ozay, Ozlen Emekci
    REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, 2021, 67 (03): : 411 - 417
  • [39] Inflammatory Markers in Women with Polycystic Ovary Syndrome
    Rudnicka, E.
    Kunicki, M.
    Suchta, K.
    Machura, P.
    Grymowicz, M.
    Smolarczyk, R.
    BIOMED RESEARCH INTERNATIONAL, 2020, 2020
  • [40] Inflammatory markers in women with polycystic ovary syndrome
    Ardawi, Mohamed S.
    Rouzi, Abdulrahim A.
    REPRODUCTIVE SCIENCES, 2008, 15 (02) : 167A - 167A