Serum microRNAs as Diagnostic Markers in Polycystic Ovary Syndrome: A Narrative Review
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Lavanya, K.
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Sri Ramachandra Inst Higher Educ & Res, Dept Biochem, Chennai 600116, Tamil Nadu, IndiaSri Ramachandra Inst Higher Educ & Res, Dept Biochem, Chennai 600116, Tamil Nadu, India
Lavanya, K.
[1
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Palaniappan, N.
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Sri Ramachandra Inst Higher Educ & Res, Dept Obstet & Gynaecol, Chennai, Tamil Nadu, IndiaSri Ramachandra Inst Higher Educ & Res, Dept Biochem, Chennai 600116, Tamil Nadu, India
Palaniappan, N.
[2
]
Vinodhini, V. M.
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SRM Med Coll Hosp & Res Ctr, Dept Biochem, Chennai, Tamil Nadu, IndiaSri Ramachandra Inst Higher Educ & Res, Dept Biochem, Chennai 600116, Tamil Nadu, India
Vinodhini, V. M.
[3
]
Silambanan, Santhi
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Sri Ramachandra Inst Higher Educ & Res, Dept Biochem, Chennai 600116, Tamil Nadu, IndiaSri Ramachandra Inst Higher Educ & Res, Dept Biochem, Chennai 600116, Tamil Nadu, India
Silambanan, Santhi
[1
]
机构:
[1] Sri Ramachandra Inst Higher Educ & Res, Dept Biochem, Chennai 600116, Tamil Nadu, India
[2] Sri Ramachandra Inst Higher Educ & Res, Dept Obstet & Gynaecol, Chennai, Tamil Nadu, India
[3] SRM Med Coll Hosp & Res Ctr, Dept Biochem, Chennai, Tamil Nadu, India
Polycystic Ovarian Syndrome (PCOS) is thought to be common worldwide among middle-aged women. Increased androgen production, recurrent anovulatory cycles and ovaries with multiple cysts are symptoms of this multiorgan endocrine condition. MicroRNAs (miRs) and several candidate genes, including CYP11A, CYP21 and CYP17, have been linked to PCOS. Singlestranded non coding RNAs known as microRNAs have been shown to alter several cell cycle processes, including metabolism, apoptosis, differentiation and proliferation. By targeting hormone receptors and their release, microRNAs influence the production of steroid hormones and play a significant role in the formation and regulation of follicular growth in the ovaries. Physiological development, including physical growth and embryonic development of the ovaries, alter the levels of microRNA expression. It has been discovered that the altered pattern of microRNAs under pathological circumstances is specific to certain disorders. Therefore, a variety of medications that are either agonists or antagonists of microRNAs may be useful in initiating tailored treatments. The profiles of microRNAs differ depending on the tissue from which they originate. Due to ribozyme activity, microRNAs are persistent and resistant to hydrolysis. Since serum microRNAs are present in various bodily fluids, they are novel markers for diseases like PCOS. The microRNA profile constantly changes depending on the pathogenic stage of the disease. There are correlations between the levels of established biomarkers and the up- and down-regulation of certain microRNAs. Furthermore, it has been found that microRNAs are more specific and sensitive than conventional biomarkers. This article was created to address the altered microRNA profiles in systemic circulation and in different ovarian tissues.
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McMaster Univ, Fac Hlth Sci, 1280 Main St West,MDCL 3500, Hamilton, ON L8S 4K1, Canada
Publ Hlth Agcy Canada, 785 Carling Ave, Ottawa, ON K1A 0K9, CanadaMcMaster Univ, Fac Hlth Sci, 1280 Main St West,MDCL 3500, Hamilton, ON L8S 4K1, Canada
Presswala, Batul
De Souza, Leanne R.
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Univ Toronto, Human Biol Program, Hlth Studies Program, Univ Coll, Room 281,15 Kings Coll Circle, Toronto, ON M5S 3H7, CanadaMcMaster Univ, Fac Hlth Sci, 1280 Main St West,MDCL 3500, Hamilton, ON L8S 4K1, Canada
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Monash Univ, Fac Med Nursing & Hlth Sci, Monash Ctr Hlth Res & Implementat, Melbourne, AustraliaMonash Univ, Fac Med Nursing & Hlth Sci, Monash Ctr Hlth Res & Implementat, Melbourne, Australia
Tay, Chau Thien
Williams, Fleur
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Monash Univ, Fac Med Nursing & Hlth Sci, Monash Sch Med, Melbourne, AustraliaMonash Univ, Fac Med Nursing & Hlth Sci, Monash Ctr Hlth Res & Implementat, Melbourne, Australia
Williams, Fleur
Mousa, Aya
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Monash Univ, Fac Med Nursing & Hlth Sci, Monash Ctr Hlth Res & Implementat, Melbourne, AustraliaMonash Univ, Fac Med Nursing & Hlth Sci, Monash Ctr Hlth Res & Implementat, Melbourne, Australia
Mousa, Aya
Teede, Helena
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Monash Univ, Fac Med Nursing & Hlth Sci, Monash Ctr Hlth Res & Implementat, Melbourne, AustraliaMonash Univ, Fac Med Nursing & Hlth Sci, Monash Ctr Hlth Res & Implementat, Melbourne, Australia
Teede, Helena
Burgert, Tania S.
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Childrens Mercy Kansas City, Div Pediat Endocrinol, Kansas City, MO USA
Childrens Mercy Kansas City, Dept Pediat, 3101 Broadway, Kansas City, MO 64111 USAMonash Univ, Fac Med Nursing & Hlth Sci, Monash Ctr Hlth Res & Implementat, Melbourne, Australia
机构:
Pomeranian Med Univ, Dept Human Nutr & Metabol, Broniewskiego 24 St, PL-71460 Szczecin, PolandPomeranian Med Univ, Dept Human Nutr & Metabol, Broniewskiego 24 St, PL-71460 Szczecin, Poland
Szczuko, Malgorzata
Kikut, Justyna
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Pomeranian Med Univ, Dept Human Nutr & Metabol, Broniewskiego 24 St, PL-71460 Szczecin, PolandPomeranian Med Univ, Dept Human Nutr & Metabol, Broniewskiego 24 St, PL-71460 Szczecin, Poland
Kikut, Justyna
Szczuko, Urszula
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Pomeranian Med Univ, Dept Human Nutr & Metabol, Broniewskiego 24 St, PL-71460 Szczecin, PolandPomeranian Med Univ, Dept Human Nutr & Metabol, Broniewskiego 24 St, PL-71460 Szczecin, Poland
Szczuko, Urszula
Szydlowska, Iwona
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Pomeranian Med Univ, Dept Gynecol Endocrinol & Gynecol Oncol, Unii Lubelskiej 1 St, PL-71256 Szczecin, PolandPomeranian Med Univ, Dept Human Nutr & Metabol, Broniewskiego 24 St, PL-71460 Szczecin, Poland
Szydlowska, Iwona
Nawrocka-Rutkowska, Jolanta
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Pomeranian Med Univ, Dept Perinatol Obstet & Gynecol, Siedlecka 2 St, PL-72010 Police, PolandPomeranian Med Univ, Dept Human Nutr & Metabol, Broniewskiego 24 St, PL-71460 Szczecin, Poland
Nawrocka-Rutkowska, Jolanta
Zietek, Maciej
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Pomeranian Med Univ, Dept Perinatol Obstet & Gynecol, Siedlecka 2 St, PL-72010 Police, PolandPomeranian Med Univ, Dept Human Nutr & Metabol, Broniewskiego 24 St, PL-71460 Szczecin, Poland
Zietek, Maciej
Verbanac, Donatella
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Univ Zagreb, Fac Pharm & Biochem, Dept Med Biochem & Hematol, A Kovacica 1, Zagreb 10000, CroatiaPomeranian Med Univ, Dept Human Nutr & Metabol, Broniewskiego 24 St, PL-71460 Szczecin, Poland
机构:
Inner Mongolia Med Univ, Dept Lab Med, Affiliated Hosp, Hohhot, Peoples R ChinaInner Mongolia Med Univ, Dept Lab Med, Affiliated Hosp, Hohhot, Peoples R China
Wang, Jing-Jing
Yan, Li
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Inner Mongolia Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp, Hohhot, Peoples R ChinaInner Mongolia Med Univ, Dept Lab Med, Affiliated Hosp, Hohhot, Peoples R China
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Near East Univ Hosp, Dept Obstet & Gynecol, Nicosia, Cyprus
Near East Univ, Res Ctr Expt Hlth Sci, Nicosia, CyprusNear East Univ Hosp, Dept Obstet & Gynecol, Nicosia, Cyprus
Ozay, Ali Cenk
Ozay, Ozlen Emekci
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Near East Univ Hosp, Dept Obstet & Gynecol, Nicosia, CyprusNear East Univ Hosp, Dept Obstet & Gynecol, Nicosia, Cyprus
Ozay, Ozlen Emekci
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