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Pediatric venous thromboembolism: incidence and patient profile in a single Brazilian institution
被引:0
作者:
Lira, Liana Ariel de Siqueira
[1
]
Carneiro, Jorge David Aivazoglou
[2
]
Duarte, Maria do Carmo Menezes Bezerra
[1
]
机构:
[1] Inst Med Integral Prof Fernando Figueira IMIP, Rua Coelhos 300, BR-50070902 Recife, PE, Brazil
[2] Univ Sao Paulo FMUSP, Inst Crianca, Hosp Clin, Fac Med, Sao Paulo, SP, Brazil
关键词:
Thrombosis;
Venous thromboembolism;
Child;
Adolescent;
HOSPITAL-ACQUIRED THROMBOSIS;
CHILDREN;
REGISTRY;
COMMUNICATION;
THROMBOPHILIA;
METAANALYSIS;
PREVENTION;
MODEL;
SSC;
D O I:
10.1016/j.htct.2024.06.006
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Background: As the diagnosis of Pediatric venous thromboembolism has dramatically increased in recent decades, this study aims to evaluate these patients, determining the incidence and describing their biological and clinical characteristics. Methods: An observational, cross-sectional study was conducted at a Brazilian quaternary hospital between January 2022 and February 2023. Under 18-year-old hospitalized patients with a confirmed diagnosis of venous thromboembolism were included, while those with arterial or chronic thrombosis were excluded. Data on biological and clinical characteristics, diagnosis and treatment were evaluated. A descriptive data analysis was performed and the incidence of hospital-associated thrombosis was calculated. Results: Thirty-nine pediatric patients were evaluated. The incidence of hospital-associated thrombosis was 19.9 cases per 10,000 pediatric hospitalizations. Median age at diagnosis was four months (range: 12 days-17 years). Most of the patients (66.7%) were asymptomatic, with venous thromboembolism being diagnosed incidentally. In all cases, at least one risk factor was identified and in 74.6% of cases four or more factors were present. The principal risk factors were the presence of a central venous catheter (89.7%) and infection (89.7%). Thrombogenic comorbidities, particularly congenital heart disease, were present in 48.7% of patients. Conclusions: The incidence of venous thromboembolism found in the present study was lower than rates reported in developed countries. The principal characteristics of this sample were a greater frequency of central venous catheter and infection as risk factors, and the fact that the cases consisted mainly of newborns and individuals with heart disease. (c) 2024 Associa & ccedil;& atilde;o Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Espa & ntilde;a, S.L.U. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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页码:S227 / S232
页数:6
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