共 46 条
Boron carbide nanoparticles for boron neutron capture therapy
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作者:

Xu, Shiwei
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Nanjing Univ, Coll Engn & Appl Sci, Nanjing 210023, Peoples R China Nanjing Univ, Coll Engn & Appl Sci, Nanjing 210023, Peoples R China

Yu, Ying
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Nanjing Univ, Coll Engn & Appl Sci, Nanjing 210023, Peoples R China Nanjing Univ, Coll Engn & Appl Sci, Nanjing 210023, Peoples R China

Zhang, Boyu
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Nanjing Univ, Coll Engn & Appl Sci, Nanjing 210023, Peoples R China Nanjing Univ, Coll Engn & Appl Sci, Nanjing 210023, Peoples R China

Zhu, Kejia
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机构:
Wuxi Xishan NJU Inst Appl Biotechnol, Wuxi 214104, Peoples R China Nanjing Univ, Coll Engn & Appl Sci, Nanjing 210023, Peoples R China

Cheng, Yuan
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Wuxi Xishan NJU Inst Appl Biotechnol, Wuxi 214104, Peoples R China Nanjing Univ, Coll Engn & Appl Sci, Nanjing 210023, Peoples R China

Zhang, Tao
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机构:
Nanjing Univ, Coll Engn & Appl Sci, Nanjing 210023, Peoples R China
Nanjing Univ, MOE Key Lab High Performance Polymer Mat & Technol, Nanjing 210023, Peoples R China
Wuxi Xishan NJU Inst Appl Biotechnol, Wuxi 214104, Peoples R China
Qinghai Inst Technol, Sch Engn, Xining 810016, Peoples R China Nanjing Univ, Coll Engn & Appl Sci, Nanjing 210023, Peoples R China
机构:
[1] Nanjing Univ, Coll Engn & Appl Sci, Nanjing 210023, Peoples R China
[2] Nanjing Univ, MOE Key Lab High Performance Polymer Mat & Technol, Nanjing 210023, Peoples R China
[3] Wuxi Xishan NJU Inst Appl Biotechnol, Wuxi 214104, Peoples R China
[4] Qinghai Inst Technol, Sch Engn, Xining 810016, Peoples R China
基金:
国家重点研发计划;
关键词:
FOLATE RECEPTOR;
CARBON DOTS;
FOLIC-ACID;
BNCT;
CHITOSAN;
TUMORS;
D O I:
10.1039/d5ra00734h
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
Boron agent is widely accepted as one of the most important factors in boron neutron capture therapy (BNCT). In this study, boron carbide (B4C) nanoparticles were subjected to chemical modification, with the folic acid moiety linked to the surface of the particles by varying the segments of the covalent linker polyethylene glycol (PEG) through gamma-aminopropyltriethoxysilane (APTES) functionalization. The resultant products were three boron agents, termed as B4C-APTES-FA, B4C-APTES-PEG2K-FA, and B4C-APTES-PEG5K-FA. A comparison was made between these products and the pristine B4C nanoparticles by investigating their physicochemical properties and biological performances, including hemolysis, cytotoxicity, and cellular uptake. Subsequently, the modified B4C-APTES-PEG2K-FA nanoparticles were subjected to in vivo safety assays and biodistribution investigations in mice at various dosages. Upon characterization using ICP-OES, it was found that the boron contents were the highest in the lungs, followed by the liver, spleen, kidneys, hearts, and tumors, and the lowest in the brain and muscles. The boron content in the tumor reached as high as 50 mu g per g of dried tissue weight after 24 h of intravenous injection (I.V.), while the tumor-to-muscle and tumor-to-brain ratios of boron contents were found to exceed 3 following 24 hours of intravenous injection. These findings suggest that B4C nanoparticles are promising for BNCT owing to their high boron content, satisfactory biocompatibility, and abundant chemical modification sites.
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页码:10717 / 10730
页数:14
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共 46 条
[1]
Biocompatibility of functionalized boron phosphate (BPO4) nanoparticles for boron neutron capture therapy (BNCT) application
[J].
Achilli, Cesare
;
Grandi, Stefania
;
Ciana, Annarita
;
Guidetti, Gianni F.
;
Malara, Alessandro
;
Abbonante, Vittorio
;
Cansolino, Laura
;
Tomasi, Corrado
;
Balduini, Alessandra
;
Fagnoni, Maurizio
;
Merli, Daniele
;
Mustarelli, Piercarlo
;
Canobbio, Ilaria
;
Balduini, Cesare
;
Minetti, Giampaolo
.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,
2014, 10 (03)
:589-597

论文数: 引用数:
h-index:
机构:

Grandi, Stefania
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pavia, Dept Chem, I-27100 Pavia, Italy Univ Pavia, Dept Biol & Biotechnol, Labs Biochem, I-27100 Pavia, Italy

Ciana, Annarita
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pavia, Dept Biol & Biotechnol, Labs Biochem, I-27100 Pavia, Italy Univ Pavia, Dept Biol & Biotechnol, Labs Biochem, I-27100 Pavia, Italy

Guidetti, Gianni F.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pavia, Dept Biol & Biotechnol, Labs Biochem, I-27100 Pavia, Italy Univ Pavia, Dept Biol & Biotechnol, Labs Biochem, I-27100 Pavia, Italy

Malara, Alessandro
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pavia, Dept Biol & Biotechnol, Labs Biochem, I-27100 Pavia, Italy

Abbonante, Vittorio
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pavia, Dept Mol Med, I-27100 Pavia, Italy Univ Pavia, Dept Biol & Biotechnol, Labs Biochem, I-27100 Pavia, Italy

Cansolino, Laura
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pavia, Dept Clinicosurg Sci, I-27100 Pavia, Italy
IRCCS, S Matteo Hosp, Pavia, Italy Univ Pavia, Dept Biol & Biotechnol, Labs Biochem, I-27100 Pavia, Italy

Tomasi, Corrado
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pavia, Dept Chem, I-27100 Pavia, Italy
Unit Lecco, CNR, fI ENI, I-23900 Lecce, Italy Univ Pavia, Dept Biol & Biotechnol, Labs Biochem, I-27100 Pavia, Italy

Balduini, Alessandra
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pavia, Dept Mol Med, I-27100 Pavia, Italy Univ Pavia, Dept Biol & Biotechnol, Labs Biochem, I-27100 Pavia, Italy

Fagnoni, Maurizio
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pavia, Dept Chem, I-27100 Pavia, Italy Univ Pavia, Dept Biol & Biotechnol, Labs Biochem, I-27100 Pavia, Italy

Merli, Daniele
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pavia, Dept Chem, I-27100 Pavia, Italy Univ Pavia, Dept Biol & Biotechnol, Labs Biochem, I-27100 Pavia, Italy

论文数: 引用数:
h-index:
机构:

论文数: 引用数:
h-index:
机构:

Balduini, Cesare
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pavia, Dept Biol & Biotechnol, Labs Biochem, I-27100 Pavia, Italy Univ Pavia, Dept Biol & Biotechnol, Labs Biochem, I-27100 Pavia, Italy

Minetti, Giampaolo
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pavia, Dept Biol & Biotechnol, Labs Biochem, I-27100 Pavia, Italy Univ Pavia, Dept Biol & Biotechnol, Labs Biochem, I-27100 Pavia, Italy
[2]
The folate receptor as a rational therapeutic target for personalized cancer treatment
[J].
Assaraf, Yehuda G.
;
Leamon, Christopher P.
;
Reddy, Joseph A.
.
DRUG RESISTANCE UPDATES,
2014, 17 (4-6)
:89-95

Assaraf, Yehuda G.
论文数: 0 引用数: 0
h-index: 0
机构:
Technion Israel Inst Technol, Fac Biol, Fred Wyszkowski Canc Res Lab, IL-32000 Haifa, Israel Technion Israel Inst Technol, Fac Biol, Fred Wyszkowski Canc Res Lab, IL-32000 Haifa, Israel

Leamon, Christopher P.
论文数: 0 引用数: 0
h-index: 0
机构:
Endocyte Inc, W Lafayette, IN USA Technion Israel Inst Technol, Fac Biol, Fred Wyszkowski Canc Res Lab, IL-32000 Haifa, Israel

Reddy, Joseph A.
论文数: 0 引用数: 0
h-index: 0
机构:
Endocyte Inc, W Lafayette, IN USA Technion Israel Inst Technol, Fac Biol, Fred Wyszkowski Canc Res Lab, IL-32000 Haifa, Israel
[3]
Chemical states of carbon in amorphous boron carbide thin films deposited by radio frequency magnetron sputtering
[J].
Bao, Rucliang
;
Chrisey, Douglas B.
.
THIN SOLID FILMS,
2010, 519 (01)
:164-168

Bao, Rucliang
论文数: 0 引用数: 0
h-index: 0
机构:
Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA

Chrisey, Douglas B.
论文数: 0 引用数: 0
h-index: 0
机构:
Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA
[4]
Boron neutron capture therapy of brain tumors - Current status and future prospects - Preface
[J].
Barth, RF
;
Soloway, AH
.
JOURNAL OF NEURO-ONCOLOGY,
1997, 33 (1-2)
:3-7

Barth, RF
论文数: 0 引用数: 0
h-index: 0
机构:
OHIO STATE UNIV,COLL PHARM,COLUMBUS,OH 43210 OHIO STATE UNIV,COLL PHARM,COLUMBUS,OH 43210

Soloway, AH
论文数: 0 引用数: 0
h-index: 0
机构:
OHIO STATE UNIV,COLL PHARM,COLUMBUS,OH 43210 OHIO STATE UNIV,COLL PHARM,COLUMBUS,OH 43210
[5]
Boron delivery agents for neutron capture therapy of cancer
[J].
Barth, Rolf F.
;
Mi, Peng
;
Yang, Weilian
.
CANCER COMMUNICATIONS,
2018, 38
:1-15

Barth, Rolf F.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Pathol, 4132 Graves Hall,333 W 10th Ave, Columbus, OH 43210 USA Ohio State Univ, Dept Pathol, 4132 Graves Hall,333 W 10th Ave, Columbus, OH 43210 USA

Mi, Peng
论文数: 0 引用数: 0
h-index: 0
机构:
Sichuan Univ, Dept Radiol, Ctr Med Imaging, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, Ctr Canc, West China Hosp, Chengdu 610041, Sichuan, Peoples R China
Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Sichuan, Peoples R China Ohio State Univ, Dept Pathol, 4132 Graves Hall,333 W 10th Ave, Columbus, OH 43210 USA

Yang, Weilian
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Pathol, 4132 Graves Hall,333 W 10th Ave, Columbus, OH 43210 USA
Suzhou Univ, Affiliated Hosp 1, Neurosurg & Brain & Nerve Res Lab, Suzhou 215004, Jiangsu, Peoples R China Ohio State Univ, Dept Pathol, 4132 Graves Hall,333 W 10th Ave, Columbus, OH 43210 USA
[6]
A realistic appraisal of boron neutron capture therapy as a cancer treatment modality
[J].
Barth, Rolf F.
;
Zhang, Zizhu
;
Liu, Tong
.
CANCER COMMUNICATIONS,
2018, 38

Barth, Rolf F.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA

Zhang, Zizhu
论文数: 0 引用数: 0
h-index: 0
机构:
Beijing Capture Technol Co Ltd, Beijing 102445, Peoples R China Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA

Liu, Tong
论文数: 0 引用数: 0
h-index: 0
机构:
Beijing Capture Technol Co Ltd, Beijing 102445, Peoples R China Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA
[7]
Principles of nanoparticle design for overcoming biological barriers to drug delivery
[J].
Blanco, Elvin
;
Shen, Haifa
;
Ferrari, Mauro
.
NATURE BIOTECHNOLOGY,
2015, 33 (09)
:941-951

Blanco, Elvin
论文数: 0 引用数: 0
h-index: 0
机构:
Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA

Shen, Haifa
论文数: 0 引用数: 0
h-index: 0
机构:
Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA
Weill Cornell Med Coll, Dept Cell & Dev Biol, New York, NY USA Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA

Ferrari, Mauro
论文数: 0 引用数: 0
h-index: 0
机构:
Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA
Weill Cornell Med Coll, Dept Med, New York, NY USA Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA
[8]
Cytotoxicity of Ag, Au and Ag-Au bimetallic nanoparticles prepared using golden rod (Solidago canadensis) plant extract
[J].
Botha, Tarryn L.
;
Elemike, Elias E.
;
Horn, Suranie
;
Onwudiwe, Damian C.
;
Giesy, John P.
;
Wepener, Victor
.
SCIENTIFIC REPORTS,
2019, 9 (1)

论文数: 引用数:
h-index:
机构:

Elemike, Elias E.
论文数: 0 引用数: 0
h-index: 0
机构:
North West Univ, Mat Sci Innovat & Modelling MaSIM Res Focus Area, Fac Agr Sci & Technol, Mafikeng Campus,Private Bag X2046, ZA-2735 Mmabatho, South Africa
North West Univ, Sch Math & Phys Sci, Fac Agr Sci & Technol, Dept Chem, Mafikeng Campus,Private Bag X2046, ZA-2735 Mmabatho, South Africa
Fed Univ Petr Resources, Coll Sci, Dept Chem, PMB 1221, Effurun, Delta State, Nigeria North West Univ, Water Res Grp, Unit Environm Sci & Management, Potchefstroom Campus,Private Bag X6001, ZA-2520 Potchefstroom, South Africa

论文数: 引用数:
h-index:
机构:

Onwudiwe, Damian C.
论文数: 0 引用数: 0
h-index: 0
机构:
North West Univ, Mat Sci Innovat & Modelling MaSIM Res Focus Area, Fac Agr Sci & Technol, Mafikeng Campus,Private Bag X2046, ZA-2735 Mmabatho, South Africa
North West Univ, Sch Math & Phys Sci, Fac Agr Sci & Technol, Dept Chem, Mafikeng Campus,Private Bag X2046, ZA-2735 Mmabatho, South Africa North West Univ, Water Res Grp, Unit Environm Sci & Management, Potchefstroom Campus,Private Bag X6001, ZA-2520 Potchefstroom, South Africa

Giesy, John P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Saskatchewan, Dept Vet Biomed Sci, Saskatoon, SK, Canada
Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK, Canada
Michigan State Univ, Dept Zool, E Lansing, MI 48824 USA
Michigan State Univ, Ctr Integrat Toxicol, E Lansing, MI 48824 USA
Univ Hong Kong, Sch Biol Sci, Hong Kong, Peoples R China
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing, Jiangsu, Peoples R China North West Univ, Water Res Grp, Unit Environm Sci & Management, Potchefstroom Campus,Private Bag X6001, ZA-2520 Potchefstroom, South Africa

论文数: 引用数:
h-index:
机构:
[9]
Folic acid-functionalized tea polyphenol as a tumor-targeting nano-drug delivery system
[J].
Chuan, Di
;
Mu, Min
;
Hou, Huan
;
Zhao, Na
;
Li, Jinglun
;
Tong, Aiping
;
Zou, Bingwen
;
Chen, Haifeng
;
Han, Bo
;
Guo, Gang
.
MATERIALS & DESIGN,
2021, 206

Chuan, Di
论文数: 0 引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Peoples R China
Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Dept Neurosurg, Chengdu 610041, Peoples R China Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

Mu, Min
论文数: 0 引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Peoples R China
Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Dept Neurosurg, Chengdu 610041, Peoples R China Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

Hou, Huan
论文数: 0 引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Peoples R China
Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Dept Neurosurg, Chengdu 610041, Peoples R China Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

Zhao, Na
论文数: 0 引用数: 0
h-index: 0
机构:
Shihezi Univ, Sch Pharm, Shihezi 832002, Peoples R China
Minist Educ, Key Lab Xinjiang Phytomed Resource & Utilizat, Shihezi 832002, Peoples R China Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

Li, Jinglun
论文数: 0 引用数: 0
h-index: 0
机构:
Southwest Med Univ, Affiliated Hosp, Dept Neurol, Luzhou 646000, Peoples R China Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

Tong, Aiping
论文数: 0 引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Peoples R China
Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Dept Neurosurg, Chengdu 610041, Peoples R China Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

Zou, Bingwen
论文数: 0 引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Peoples R China
Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Dept Neurosurg, Chengdu 610041, Peoples R China Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

Chen, Haifeng
论文数: 0 引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Peoples R China
Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Dept Neurosurg, Chengdu 610041, Peoples R China Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

Han, Bo
论文数: 0 引用数: 0
h-index: 0
机构:
Shihezi Univ, Sch Pharm, Shihezi 832002, Peoples R China
Minist Educ, Key Lab Xinjiang Phytomed Resource & Utilizat, Shihezi 832002, Peoples R China Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

Guo, Gang
论文数: 0 引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Peoples R China
Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Dept Neurosurg, Chengdu 610041, Peoples R China Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
[10]
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment
[J].
Coghi, Paolo
;
Li, Jinxin
;
Hosmane, Narayan S.
;
Zhu, Yinghuai
.
MEDICINAL RESEARCH REVIEWS,
2023, 43 (05)
:1809-1830

Coghi, Paolo
论文数: 0 引用数: 0
h-index: 0
机构:
Macau Univ Sci & Technol, Sch Pharm, Macau, Peoples R China Macau Univ Sci & Technol, Sch Pharm, Macau, Peoples R China

Li, Jinxin
论文数: 0 引用数: 0
h-index: 0
机构:
Macau Univ Sci & Technol, Sch Pharm, Macau, Peoples R China Macau Univ Sci & Technol, Sch Pharm, Macau, Peoples R China

Hosmane, Narayan S.
论文数: 0 引用数: 0
h-index: 0
机构:
Northern Illinois Univ, Dept Chem & Biochem, De Kalb, IL USA Macau Univ Sci & Technol, Sch Pharm, Macau, Peoples R China

Zhu, Yinghuai
论文数: 0 引用数: 0
h-index: 0
机构:
Sunshine Lake Pharm Co Ltd, Dongguan, Peoples R China
Sunshine Lake Pharm Co Ltd, Dongguan 523871, Peoples R China Macau Univ Sci & Technol, Sch Pharm, Macau, Peoples R China