Despicable role of epithelial-mesenchymal transition in breast cancer metastasis: Exhibiting de novo restorative regimens

被引：5

作者：

Famta, Paras ^{[1
]}

Shah, Saurabh ^{[1
]}

Dey, Biswajit ^{[2
]}

Kumar, Kondasingh Charan ^{[1
]}

Bagasariya, Deepkumar ^{[1
]}

Vambhurkar, Ganesh ^{[1
]}

Pandey, Giriraj ^{[1
]}

Sharma, Anamika ^{[2
]}

Srinivasarao, Dadi A. ^{[1
]}

Kumar, Rahul ^{[2
]}

Guru, Santosh Kumar ^{[2
]}

Raghuvanshi, Rajeev Singh ^{[3
]}

Srivastava, Saurabh ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res NIPER, Dept Pharmaceut, Pharmaceut Innovat & Translat Res Lab PITRL, Hyderabad 500037, Telangana, India

[2] Natl Inst Pharmaceut Educ & Res NIPER, Dept Biol Sci, Hyderabad 500037, India

[3] Govt India, Cent Drugs Stand Control Org, New Delhi 110002, India

来源：

CANCER PATHOGENESIS AND THERAPY | 2025年 / 3卷 / 01期

关键词：

Breast cancer; Epithelial-to-mesenchymal transition; Metastases; Cancer stem cells; Epigenetics; STEM-CELLS; SUPPRESSOR-CELLS; MULTIDRUG-RESISTANCE; SIGNALING PATHWAY; PARP INHIBITORS; GENE-EXPRESSION; UP-REGULATION; EMT; PROMOTES; FIBROBLASTS;

D O I：

10.1016/j.cpt.2024.01.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer (BC) is the most prevalent cancer in women globally. Anti-cancer advancements have enabled the killing of BC cells through various therapies; however, cancer relapse is still a major limitation and decreases patient survival and quality of life. Epithelial-to-mesenchymal transition (EMT) is responsible for tumor relapse in several cancers. This highly regulated event causes phenotypic, genetic, and epigenetic changes in the tumor microenvironment (TME). This review summarizes the recent advancements regarding EMT using dedifferentiation and partial EMT theories. We extensively review the mechanistic pathways, TME components, and various anti-cancer adjuvant and neo-adjuvant therapies responsible for triggering EMT in BC tumors. Information regarding essential clinical studies and trials is also discussed. Furthermore, we also highlight the recent strategies targeting various EMT pathways. This review provides a holistic picture of BC biology, molecular pathways, and recent advances in therapeutic strategies.

引用

页码：30 / 47

页数：18

共 244 条

[1] EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration [J].