Ni-Catalyzed Synthesis of Multisubstituted Allenes via Reductive Cross-Coupling of Propargylic Acetates with Chlorohydrosilanes

This paper introduces an innovative strategy for the synthesis of multisubstituted allenes via nickel-catalyzed reductive cross-coupling reactions. The approach utilizes propargyl acetates and chlorosilanes to produce a variety of silyl-substituted allenes. The reaction conditions are notably mild, and the process is characterized by high chemo- and regioselectivity, as well as an impressive substrate scope. Furthermore, the method can be readily extended to the use of chlorogermane and chlorostannane, facilitating the synthesis of germanium or stannium-substituted allenes. This research not only offers a valuable strategy for the preparation of multisubstituted allenes but also significantly broadens the synthetic repertoire for the construction of highly functionalized molecules.