Asthmatic patients with vitamin D deficiency: Can vitamin D supplementation make a difference

被引:1
作者
Niu, Haiying [1 ]
He, Huijie [1 ]
Zhao, Zilong [1 ]
Lu, Xuemei [2 ]
Zhao, Gang [1 ]
机构
[1] Baotou Med Coll, Dept Pulm Med, Affiliated Hosp 1, Baotou, Peoples R China
[2] Baotou Med Coll, Affiliated Hosp 1, Dept Teaching, Baotou, Peoples R China
关键词
Asthma; VitD; FEV; lung function; 25-hydroxyVitD; METAANALYSIS; MODERATE; CHILDREN;
D O I
10.3233/THC-231462
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
BACKGROUND: Asthma is a major public health concern due to its persistent inflammation of the airways. The intricate and widely variable epidemiology of asthma among nations and populations is a result of the interplay between genetic, environmental, and socioeconomic factors. OBJECTIVE: This study aims to investigate whether VitD supplementation can reduce the frequency of exacerbations (including the frequency of exacerbations requiring systemic corticosteroids and the frequency of exacerbations necessitating trips to the hospital or emergency room, or both) and improve pulmonary function (clinical indicators such as the FEV1% predicted value). METHODS: Computers were used to search Pubmed, Medline, ISI Web of Science, Embase, Cachrane Library, CNKI, CBM, VIP, and the Wanfang Database. Asthma/asthma, VitD/VitD, lung function/lung function, retrieval time is from database setup to October 8, 2021, to search all randomized controlled trials (RCTs) on the effect of VitD on human asthma and to retroactively incorporate references to literature were all included in the search criteria. After rigorous screening, quality evaluation, and data extraction of the included literature by two reviewers independently, heterogeneity tests and sensitivity analyses were performed. RESULTS: The findings show that a total of 12 relevant studies meeting the inclusion criteria were finally included, including 649 cases in the experimental group and 646 cases in the control group. VitD intervention reduced the number of asthma exacerbations, including the rate of exacerbations requiring systemic corticosteroid therapy and the rate of acute exacerbations requiring emergency department or hospital visits or both. CONCLUSIONS: In the outcome of lung function (FEV1% predicted value), it was shown that VitD supplementation improved lung function; in the outcome of serum 25-hydroxyVitD levels, it was shown that VitD supplementation increased serum 25-hydroxyVitD levels.
引用
收藏
页码:3985 / 4008
页数:24
相关论文
共 50 条
[41]   Safety and efficacy of a new supplementation protocol in patients with cystic fibrosis and vitamin D deficiency [J].
Sanchez, Carmen Mangas ;
Garcia, Maria Garriga ;
Nieto, Maria Juliana Serrano ;
Garcia-Romero, Ruth ;
Beltran, Marina alvarez ;
Crehua-Gaudiza, Elena ;
Santamaria, Saioa Vicente ;
Costa, Cecilia Martinez ;
Martin, Juan Jose Diaz ;
Garcia, Carlos Bousono ;
Jimenez, David Gonzalez .
ANALES DE PEDIATRIA, 2023, 98 (04) :257-266
[42]   Prospective cohort study of vitamin D deficiency in pregnancy: Prevalence and limited effectiveness of 1000 IU vitamin D supplementation [J].
Abdelmageed, Rasha Mohammed ;
Hussein, Suha Majeed Mohammed ;
Anamangadan, Shamil Mohamed ;
Abdullah, Rola Walid Mahmoud ;
Rauf, Lubna ;
Alfehaidi, AlAnoud Saleh ;
Hamed, Ehab .
WOMENS HEALTH, 2024, 20
[43]   Does Vitamin D Work Synergistically with Anti-Asthmatic Drugs in Airway Remodeling? [J].
Sobczak, Marharyta ;
Pawliczak, Rafal .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (21)
[44]   Vitamin D status among children and adolescents in an Egyptian cohort: can we predict vitamin D deficiency? [J].
Karem, Mona ;
Heiba, Ebtehal Gamal ;
Kamel, Noha ;
Gad, Suzan .
HORMONE RESEARCH IN PAEDIATRICS, 2019, 91 :638-639
[45]   Vitamin D Levels of Asthmatic Children with and Without Obesity [J].
Erkocoglu, Mustafa ;
Capanoglu, Murat ;
Civelek, Ersoy ;
Kaya, Aysenur ;
Ginis, Zeynep ;
Toyran, Mge ;
Dibek Misirlioglu, Emine ;
Kocabas, Can Naci .
ASIM ALLERJI IMMUNOLOJI, 2016, 14 (01) :25-30
[46]   Vitamin D and pulmonary function in obese asthmatic children [J].
Lautenbacher, Laura A. ;
Jariwala, Sunit P. ;
Markowitz, Morri E. ;
Rastogi, Deepa .
PEDIATRIC PULMONOLOGY, 2016, 51 (12) :1276-1283
[47]   Vitamin D supplementation and recombinant human erythropoietin utilization in vitamin D-deficient hemodialysis patients [J].
Kumar, Victoria A. ;
Kujubu, Dean A. ;
Sim, John J. ;
Rasgon, Scott A. ;
Yang, Philip S. .
JOURNAL OF NEPHROLOGY, 2011, 24 (01) :98-105
[48]   Vitamin D levels and vitamin D receptor gene polymorphisms in asthmatic children: a case-control study [J].
Einisman, Helly ;
Loreto Reyes, Maria ;
Angulo, Jenniffer ;
Cerda, Jaime ;
Lopez-Lastra, Marcelo ;
Castro-Rodriguez, Jose A. .
PEDIATRIC ALLERGY AND IMMUNOLOGY, 2015, 26 (06) :545-550
[49]   Vitamin D Supplementation in Patients with Chronic Kidney Disease [J].
Cheriet, Sarah ;
Royer, Matthieu ;
Rajzbaum, Gerald ;
Tremollieres, Florence .
JOINT BONE SPINE, 2012, 79 :S110-S113
[50]   Vitamin D Supplementation and the Risk of Colds in Patients with Asthma [J].
Denlinger, Loren C. ;
King, Tonya S. ;
Cardet, Juan Carlos ;
Craig, Timothy ;
Holguin, Fernando ;
Jackson, Daniel J. ;
Kraft, Monica ;
Peters, Stephen P. ;
Ross, Kristie ;
Sumino, Kaharu ;
Boushey, Homer A. ;
Jarjour, Nizar N. ;
Wechsler, Michael E. ;
Wenzel, Sally E. ;
Castro, Mario ;
Avila, Pedro C. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, 193 (06) :634-641