Asthmatic patients with vitamin D deficiency: Can vitamin D supplementation make a difference

被引:0
作者
Niu, Haiying [1 ]
He, Huijie [1 ]
Zhao, Zilong [1 ]
Lu, Xuemei [2 ]
Zhao, Gang [1 ]
机构
[1] Baotou Med Coll, Dept Pulm Med, Affiliated Hosp 1, Baotou, Peoples R China
[2] Baotou Med Coll, First Affiliated Hosp, Dept Teaching, Baotou, Peoples R China
关键词
Asthma; VitD; FEV; lung function; 25-hydroxyVitD; METAANALYSIS; MODERATE; CHILDREN;
D O I
10.3233/THC-231462
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
BACKGROUND: Asthma is a major public health concern due to its persistent inflammation of the airways. The intricate and widely variable epidemiology of asthma among nations and populations is a result of the interplay between genetic, environmental, and socioeconomic factors. OBJECTIVE: This study aims to investigate whether VitD supplementation can reduce the frequency of exacerbations (including the frequency of exacerbations requiring systemic corticosteroids and the frequency of exacerbations necessitating trips to the hospital or emergency room, or both) and improve pulmonary function (clinical indicators such as the FEV1% predicted value). METHODS: Computers were used to search Pubmed, Medline, ISI Web of Science, Embase, Cachrane Library, CNKI, CBM, VIP, and the Wanfang Database. Asthma/asthma, VitD/VitD, lung function/lung function, retrieval time is from database setup to October 8, 2021, to search all randomized controlled trials (RCTs) on the effect of VitD on human asthma and to retroactively incorporate references to literature were all included in the search criteria. After rigorous screening, quality evaluation, and data extraction of the included literature by two reviewers independently, heterogeneity tests and sensitivity analyses were performed. RESULTS: The findings show that a total of 12 relevant studies meeting the inclusion criteria were finally included, including 649 cases in the experimental group and 646 cases in the control group. VitD intervention reduced the number of asthma exacerbations, including the rate of exacerbations requiring systemic corticosteroid therapy and the rate of acute exacerbations requiring emergency department or hospital visits or both. CONCLUSIONS: In the outcome of lung function (FEV1% predicted value), it was shown that VitD supplementation improved lung function; in the outcome of serum 25-hydroxyVitD levels, it was shown that VitD supplementation increased serum 25-hydroxyVitD levels.
引用
收藏
页码:3985 / 4008
页数:24
相关论文
共 50 条
  • [21] The effects of vitamin D supplementation on postoperative atrial fibrillation after coronary artery bypass grafting in patients with vitamin D deficiency
    Talasaz, Azita H.
    Salehiomran, Abbas
    Heidary, Zinat
    Gholami, Kheirollah
    Aryannejad, Hamid
    Jalali, Arash
    Daei, Maryam
    JOURNAL OF CARDIAC SURGERY, 2022, 37 (07) : 2219 - 2224
  • [22] Randomized Controlled Trial (RCT) of Vitamin D Supplementation in Pregnancy in a Population With Endemic Vitamin D Deficiency
    Dawodu, Adekunle
    Saadi, Hussein F.
    Bekdache, Gharid
    Javed, Yasin
    Altaye, Mekibib
    Hollis, Bruce W.
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2013, 98 (06) : 2337 - 2346
  • [23] Correlation between the vitamin D levels and asthma attacks in children: Evaluation of the effects of combination therapy of atomization inhalation of budesonide, albuterol and vitamin D supplementation on asthmatic patients
    Kang, Qinhong
    Zhang, Xiaoying
    Liu, Shanjuan
    Huang, Fang
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2018, 15 (01) : 727 - 732
  • [24] Effects of Pre-Natal Vitamin D Supplementation with Partial Correction of Vitamin D Deficiency on Early Life Healthcare Utilisation: A Randomised Controlled Trial
    Griffiths, Megan
    Goldring, Stephen
    Griffiths, Chris
    Shaheen, Seif O.
    Martineau, Adrian
    Cross, Louise
    Robinson, Stephen
    Warner, John O.
    Devine, Angela
    Boyle, Robert J.
    PLOS ONE, 2015, 10 (12):
  • [25] Vitamin D levels, vitamin D supplementation, and prognosis in patients with chronic kidney disease
    Namir, Yossef
    Cohen, Matan J.
    Haviv, Yosef S.
    Slotki, Itzchak
    Shavit, Linda
    CLINICAL NEPHROLOGY, 2016, 86 (04) : 165 - 174
  • [26] Ergocalciferol Supplementation in Hemodialysis Patients With Vitamin D Deficiency: A Randomized Clinical Trial
    Miskulin, Dana C.
    Majchrzak, Karen
    Tighiouart, Hocine
    Muther, Richard S.
    Kapoian, Toros
    Johnson, Doug S.
    Weiner, Daniel E.
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2016, 27 (06): : 1801 - 1810
  • [27] Vitamin D deficiency
    Gani, Linsey Utami
    How, Choon How
    SINGAPORE MEDICAL JOURNAL, 2015, 56 (08) : 433 - 436
  • [28] The role of oral vitamin D3 supplementation in the treatment of Chronic Rhinosinusitis in adults with Vitamin D deficiency
    Baruah, Binayak
    Gupta, Ajay
    Kumar, Abhijit
    Kumar, Alok
    JOURNAL OF FAMILY MEDICINE AND PRIMARY CARE, 2020, 9 (06) : 2877 - 2879
  • [29] Correction of vitamin D deficiency in a cohort of newborn infants using daily 200 IU vitamin D supplementation
    Onwuneme, C.
    Diya, B.
    Uduma, O.
    McCarthy, R. A.
    Murphy, N.
    Kilbane, M. T.
    McKenna, M. J.
    Molloy, E. J.
    IRISH JOURNAL OF MEDICAL SCIENCE, 2016, 185 (03) : 683 - 687
  • [30] Evaluation of serum 25-hidroxy vitamin D and zinc levels in asthmatic patients
    Elevli, Murat
    Bozaci, Ayse Ergul
    Sahin, Kamil
    Duru, Hatice Nilgun
    Civilibal, Mahmut
    Aktas, Baris Belgin
    TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, 2018, 43 (01): : 49 - 56