Extraction, purification, structural characterization, bioactivities, modifications and structure-activity relationship of polysaccharides from Ophiopogon japonicus: a review

被引：4
作者：
Zhang, Yiqiang [1 ]
Chen, Bo [2 ,3 ]
Zhang, Hua [4 ]
Zhang, Juan [1 ]
Xue, Juan [4 ,5 ]
机构：
[1] Jingmen Hosp Tradit Chinese Med, Dept Resp & Crit Med, Jingmen, Peoples R China
[2] China Three Gorges Univ, Peoples Hosp 2, Dept Gastroenterol, Yichang, Peoples R China
[3] Second Peoples Hosp Yichang, Dept Gastroenterol, Yichang, Peoples R China
[4] Hubei Prov Hosp Integrated Chinese & Western Med, Dept Gastroenterol, Wuhan, Peoples R China
[5] Hubei Univ Chinese Med, Sch Clin Med, Wuhan, Peoples R China
来源：
FRONTIERS IN NUTRITION | 2024年 / 11卷
关键词：
Ophiopogon japonicus; polysaccharides; extraction methods; structural characterization; biological activities; structure-activity relationship; FATTY LIVER-DISEASE; RADIX OPHIOPOGONIS; AUGMENTS SURVIVAL; GUT MICROBIOTA; MOUSE MODEL; MDG-1; LIPOSOME; ROOT; ULTRASOUND; APOPTOSIS;
D O I：
10.3389/fnut.2024.1484865
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Ophiopogon japonicus (Thunb.) Ker Gawl., is a traditional Chinese medicine (TCM) with a history of thousands of years. O. japonicus polysaccharides (OJPs), as one of the main active ingredient, are a kind of representative pharmacological bioactive macromolecules and mainly composed of Glc and Fru with molecular weight between 2.48 and 325 kDa. OJPs have a variety of biological activities, such as hypoglycemic, cardioprotective, immunomodulatory, improvement of obesity, and renal protective activity. In this review, the extraction, purification and structural characterization of OJPs were systematically reviewed, and its biological function, molecular mechanism and structure-activity relationship were analyzed. Additionally, this review summarized and found that structural modifications such as liposome modification, sulfation modification, and polyethylene glycol modification have improved the pharmacological activity and bioavailability of OJPs. Overall, this work will help to better understand OJPs and provide a theoretical review of their further development and utilization in the field of medicine and health food.
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页数：20
相关论文
共 105 条
[1]  
Algefare Abdulmohsen I, 2024, Toxicol Rep, V12, P128, DOI [10.1016/j.toxrep.2024.01.007, 10.1016/j.toxrep.2024.01.007]
[2]   Extraction, purification, structural characterization and biological activity of polysaccharides from Fritillaria: A review [J].
Borjigin, Gilwa ;
Wei, Fanshu ;
Jiang, Shuang ;
Li, Qi ;
Yang, Chunjuan .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 242
[3]   Cardiac resident macrophages: The core of cardiac immune homeostasis [J].
Cai, Wenhui ;
Lian, Lu ;
Li, Aolin ;
Zhang, Qianqian ;
Li, Mengmeng ;
Zhang, Junping ;
Xie, Yingyu .
CELLULAR SIGNALLING, 2024, 119
[4]   Comparison of Ophiopogon japonicus and Liriope spicata var. prolifera from Different Origins Based on Multi-Component Quantification and Anticancer Activity [J].
Chen, Min-Hui ;
Leong, Fong ;
Gao, Si-Jia ;
Chen, Xin ;
Lu, Jin-Jian ;
Lin, Li-Gen ;
Wang, Yitao ;
Chen, Xiao-Jia .
MOLECULES, 2023, 28 (03)
[5]   Protective effect of the polysaccharide from Ophiopogon japonicus on streptozotocin-induced diabetic rats [J].
Chen, Xiaoming ;
Tang, Jia ;
Xie, Wenyuan ;
Wang, Junjun ;
Jin, Jing ;
Ren, Jun ;
Jin, Liqin ;
Lu, Jianxin .
CARBOHYDRATE POLYMERS, 2013, 94 (01) :378-385
[6]   Extraction, purification, characterization and hypoglycemic activity of a polysaccharide isolated from the root of Ophiopogon japonicus [J].
Chen, Xiaoming ;
Jin, Jing ;
Tang, Jia ;
Wang, Zhongfu ;
Wang, Junjun ;
Jin, Liqin ;
Lu, Jianxin .
CARBOHYDRATE POLYMERS, 2011, 83 (02) :749-754
[7]   Quality Evaluation of Ophiopogon japonicus from Two Authentic Geographical Origins in China Based on Physicochemical and Pharmacological Properties of Their Polysaccharides [J].
Chen, Zherui ;
Zhu, Baojie ;
Peng, Xin ;
Li, Shaoping ;
Zhao, Jing .
BIOMOLECULES, 2022, 12 (10)
[8]  
China Pharmacopoeia Commission, 2015, Chinese pharmacopeia, P26
[9]   Small metabolites, possible big changes: a microbiota-centered view of non-alcoholic fatty liver disease [J].
Chu, Huikuan ;
Duan, Yi ;
Yang, Ling ;
Schnabl, Bernd .
GUT, 2019, 68 (02) :359-370
[10]   Ophiopogon Polysaccharide Liposome Regulated the Immune Activity of Kupffer Cell through miR-4796 [J].
Cui, Jing ;
Pan, Xingxue ;
Duan, Xueqin ;
Ke, Liting ;
Song, Xiaoping ;
Zhang, Weimin ;
Ma, Wuren ;
Liu, Yingqiu ;
Fan, Yunpeng .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (23)
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