I-Spin live, an open-source software based on blind-source separation for real-time decoding of motor unit activity in humans

被引:1
作者
Rossato, Julien [1 ]
Hug, Francois [2 ,3 ]
Tucker, Kylie [3 ]
Gibbs, Ciara [4 ]
Lacourpaille, Lilian [1 ]
Farina, Dario [4 ]
Avrillon, Simon [4 ]
机构
[1] Nantes Univ, Lab Movement Interact Performance UR 4334, Nantes, France
[2] Univ Cote Azur, LAMHESS, Nice, France
[3] Univ Queensland, Sch Biomed Sci, Brisbane, Qld, Australia
[4] Imperial Coll London, Fac Engn, Dept Bioengn, London, England
来源
ELIFE | 2024年 / 12卷
基金
欧洲研究理事会; 英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;
关键词
electromyography; motor unit; decomposition; neural decoding; ACTION-POTENTIALS; IDENTIFICATION; PHYSIOLOGY;
D O I
10.7554/eLife.88670
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Decoding the activity of individual neural cells during natural behaviours allows neuroscientists to study how the nervous system generates and controls movements. Contrary to other neural cells, the activity of spinal motor neurons can be determined non-invasively (or minimally invasively) from the decomposition of electromyographic (EMG) signals into motor unit firing activities. For some interfacing and neuro-feedback investigations, EMG decomposition needs to be performed in real time. Here, we introduce an open-source software that performs real-time decoding of motor neurons using a blind-source separation approach for multichannel EMG signal processing. Separation vectors (motor unit filters) are optimised for each motor unit from baseline contractions and then re-applied in real time during test contractions. In this way, the firing activity of multiple motor neurons can be provided through different forms of visual feedback. We provide a complete framework with guidelines and examples of recordings to guide researchers who aim to study movement control at the motor neuron level. We first validated the software with synthetic EMG signals generated during a range of isometric contraction patterns. We then tested the software on data collected using either surface or intramuscular electrode arrays from five lower limb muscles (gastrocnemius lateralis and medialis, vastus lateralis and medialis, and tibialis anterior). We assessed how the muscle or variation of contraction intensity between the baseline contraction and the test contraction impacted the accuracy of the real-time decomposition. This open-source software provides a set of tools for neuroscientists to design experimental paradigms where participants can receive real-time feedback on the output of the spinal cord circuits.
引用
收藏
页数:23
相关论文
共 57 条
  • [11] Tutorial: Analysis of motor unit discharge characteristics from high-density surface EMG signals
    Del Vecchio, A.
    Holobar, A.
    Falla, D.
    Felici, F.
    Enoka, R. M.
    Farina, D.
    [J]. JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY, 2020, 53
  • [12] Principles of human movement augmentation and the challenges in making it a reality
    Eden, Jonathan
    Braecklein, Mario
    Ibanez, Jaime
    Barsakcioglu, Deren Yusuf
    Di Pino, Giovanni
    Farina, Dario
    Burdet, Etienne
    Mehring, Carsten
    [J]. NATURE COMMUNICATIONS, 2022, 13 (01)
  • [13] Enoka RM, 2001, MUSCLE NERVE, V24, P4, DOI 10.1002/1097-4598(200101)24:1<4::AID-MUS13>3.0.CO
  • [14] 2-F
  • [15] The extraction of neural strategies from the surface EMG
    Farina, D
    Merletti, R
    Enoka, RM
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 2004, 96 (04) : 1486 - 1495
  • [16] Detecting the unique representation of motor-unit action potentials in the surface electromyogram
    Farina, Dario
    Negro, Francesco
    Gazzoni, Marco
    Enoka, Roger M.
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 2008, 100 (03) : 1223 - 1233
  • [17] Multichannel thin-film electrode for intramuscular electromyographic recordings
    Farina, Dario
    Yoshida, Ken
    Stieglitz, Thomas
    Koch, Klaus Peter
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 2008, 104 (03) : 821 - 827
  • [18] Toward higher-performance bionic limbs for wider clinical use
    Farina, Dario
    Vujaklija, Ivan
    Branemark, Rickard
    Bull, Anthony M. J.
    Dietl, Hans
    Graimann, Bernhard
    Hargrove, Levi J.
    Hoffmann, Klaus-Peter
    Huang, He
    Ingvarsson, Thorvaldur
    Janusson, Hilmar Bragi
    Kristjansson, Kristleifur
    Kuiken, Todd
    Micera, Silvestro
    Stieglitz, Thomas
    Sturma, Agnes
    Tyler, Dustin
    Weir, Richard F. Ff
    Aszmann, Oskar C.
    [J]. NATURE BIOMEDICAL ENGINEERING, 2023, 7 (04) : 473 - 485
  • [19] Principles of Motor Unit Physiology Evolve With Advances in Technology
    Farina, Dario
    Negro, Francesco
    Muceli, Silvia
    Enoka, Roger M.
    [J]. PHYSIOLOGY, 2016, 31 (02) : 83 - 94
  • [20] Characterization of Human Motor Units From Surface EMG Decomposition
    Farina, Dario
    Holobar, Ales
    [J]. PROCEEDINGS OF THE IEEE, 2016, 104 (02) : 353 - 373